419 results found
    1. Biochemistry and Chemical Biology

    Enterococcus faecium secreted antigen A generates muropeptides to enhance host immunity and limit bacterial pathogenesis

    Byungchul Kim et al.
    Enterococci faecium encodes unique peptidoglycan composition and remodeling activity that activates host immunity.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Cas9+ conditionally-immortalized macrophages as a tool for bacterial pathogenesis and beyond

    Allison W Roberts et al.
    Combination of stem cell engineering and CRISPR technologies created a facile method to genetically manipulate macrophages, a multifunctional cell type that plays critical roles in immunity, cancer, and tissue homeostasis.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction

    Cherilyn A Elwell et al.
    Structure of a pathogen effector complexed to Sorting Nexin 5 reveals an evolutionarily conserved interface that is required for retromer-dependent host restriction.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Acidic pH and divalent cation sensing by PhoQ are dispensable for systemic salmonellae virulence

    Kevin G Hicks et al.
    Receptor recognition of antimicrobial peptides is important for Salmonellae to survive inside macrophages and cause disease.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis

    Chi G Weindel et al.
    Long studied in the context of the central nervous system, LRRK2 also functions in peripheral immunity by maintaining mitochondrial homeostasis in macrophages to regulate the type I interferon response.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Parkinson’s Disease: Linking mitochondria to the immune response

    Rebecca L Wallings et al.
    A gene associated with Parkinson’s disease regulates mitochondrial homeostasis, thus affecting innate immunity.
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    1. Microbiology and Infectious Disease

    A protein secreted by the Salmonella type III secretion system controls needle filament assembly

    Junya Kato et al.
    A novel component of type III protein secretion systems involved in the assembly of the secretion machine is reported.
    1. Microbiology and Infectious Disease

    Visualization of the type III secretion mediated Salmonella–host cell interface using cryo-electron tomography

    Donghyun Park et al.
    Visualization of the type III secretion mediated Salmonella-host cell interface reveals the intact translocon and the profound remodeling of the host membrane at unprecedented resolution.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    A structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family

    Qing Yao et al.
    Protein heptosyltransferases modify a group of bacterial autotransporters for virulence function and employ a novel structural mechanism for the processive hyperglycosylation of the autotransporter.
    1. Microbiology and Infectious Disease

    Bacteria: Exploring new horizons

    Vineetha M Zacharia, Matthew F Traxler
    Streptomyces bacteria employ a newly-discovered cell type, the "explorer" cell, to rapidly colonize new areas in the face of competition.
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