1,871 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Olfactory responses of Drosophila are encoded in the organization of projection neurons

    Kiri Choi, Won Kyu Kim, Changbong Hyeon
    The organization of olfactory projection neurons and their synaptic connectivity with third-order neurons studied along with olfactory responses suggest that the labeled-line design is partially at work in the Drosophila olfactory system.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Altered temporal sequence of transcriptional regulators in the generation of human cerebellar granule cells

    Hourinaz Behesti, Arif Kocabas ... Mary E Hatten
    Human pluripotent stem cell modeling of the ATOH1 lineage identifies a temporal shift in the expression of key transcriptional regulators in the developing human cerebellum, this molecular divergence may drive the protracted development of the human cerebellum compared to rodents.
    1. Evolutionary Biology

    Host-pathogen coevolution increases genetic variation in susceptibility to infection

    Elizabeth ML Duxbury, Jonathan P Day ... Ben Longdon
    A history of coevolution increases genetic variation in the susceptibility of Drosophila to viruses, largely by introducing major-effect resistance polymorphisms into populations.
    1. Cell Biology

    Cellular hallmarks reveal restricted aerobic metabolism at thermal limits

    Aitana Neves, Coralie Busso, Pierre Gönczy
    Cellular hallmarks of thermal limits are evolutionarily conserved in nematodes, and changes in surface to volume ratio reflect restricted aerobic metabolism at these limits.
    1. Neuroscience
    2. Physics of Living Systems

    Continuous odor profile monitoring to study olfactory navigation in small animals

    Kevin S Chen, Rui Wu ... Andrew M Leifer
    To study odor-guided navigation of small animals such as worms and fly larvae, a novel flow chamber and odor sensor array are presented that better characterize the odors that the animal experiences.
    1. Cancer Biology

    PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis

    Norihiro Yamaguchi, Ethan M Weinberg ... Sohail F Tavazoie
    The gluconeogenic enzyme PCK1 and pyrimidine nucleotide biosynthetic enzyme DHODH drive hypoxic pyrimidine nucleotide biosynthesis and liver metastatic colonization in colorectal cancer, which is therapeutically exploitable by DHODH pharmacologic inhibition.
    1. Computational and Systems Biology

    Evolutionary dynamics of incubation periods

    Bertrand Ottino-Loffler, Jacob G Scott, Steven H Strogatz
    Evolutionary graph theory solves the longstanding puzzle of why diverse infectious diseases and cancers show similar (approximately lognormal) distributions of their incubation periods.
    1. Evolutionary Biology

    Selection and the direction of phenotypic evolution

    François Mallard, Bruno Afonso, Henrique Teotónio
    Predicting multivariate phenotypic evolution.
    1. Immunology and Inflammation

    Differential impact of self and environmental antigens on the ontogeny and maintenance of CD4+ T cell memory

    Thea Hogan, Maria Nowicka ... Benedict Seddon
    Comparing mice in clean and dirty environments reveals that environment drives initial establishment and size of T cell memory compartments, but not their maintenance in adults.
    1. Neuroscience

    Chronic exposure to odors at naturally occurring concentrations triggers limited plasticity in early stages of Drosophila olfactory processing

    Zhannetta V Gugel, Elizabeth G Maurais, Elizabeth J Hong
    Chronic stimulation with odors at naturally occurring concentrations only mildly impacts early stages of olfactory processing, suggesting a need to re-interpret prevailing models of how chronic odor exposure affects olfactory function.

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