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Project Rephetio combines data integration and systematic analysis to enable drug repurposing predictions on an unprecedented scale.

A simple and accessible method for high-throughput super-resolution fluorescence microscopy that is compatible with commonly used staining practices, 96-well cell culture plates, and confocal microscopes.

SiR does not revert to wild type when produced in high-TEVp cell lines, is non-toxic in vivo, maintains transsynaptic spreading capabilities and revertant mutations do not accumulate during in vivo experiments.

A principle from which the neuronal dynamics and synaptic plasticity in arbitrary network architectures can be inferred, so that output errors are online minimized while simultaneously processing sensory input streams.

The lysosomal ion channel TPC2 emerges as an example of an ion channel in which ion selectivity is not fixed but rather agonist-selective.

Neural activity in motor cortex displays unexpected properties, making it possible to accurately decode behavior using a straightforward and interpretable approach.

miR-125 functions as a potential dietary restriction mimetic by promoting longevity through regulation of fat metabolism.

The prediction of specific words is associated with distinct spatial and temporal patterns of neural activity within the left inferior and medial temporal regions before the predicted word is presented.

Biochemical and structural investigations of the pH adaptability of mouse Acidic Mammalian Chitinase offer insights for designing enhanced enzyme variants that can function in both lung and gut.