37 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Subtle selectivity in a pheromone sensor triumvirate desynchronizes competence and predation in a human gut commensal

    Johann Mignolet, Guillaume Cerckel ... Pascal Hols
    A new cell–cell communication system in Streptococcus salivarius, a human gut commensal, discriminates between close signaling molecules to specifically produce bacteriocin-based antimicrobials and disconnects it from foreign DNA acquisition.
    1. Microbiology and Infectious Disease

    Contact-dependent killing by Caulobacter crescentus via cell surface-associated, glycine zipper proteins

    Leonor García-Bayona, Monica S Guo, Michael T Laub
    Genetic, biochemical, and cell biological approaches reveal a new form of contact-dependent inhibition in bacteria involving bacteriocin-like proteins that aggregate on the surface of cells.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Colicin E1 opens its hinge to plug TolC

    S Jimmy Budiardjo, Jacqueline J Stevens ... Joanna SG Slusky
    Bacterial warfare protein colicin E1 opens its hinge to plug antibiotic efflux pump TolC and potentiate antibiotics.
    1. Ecology
    2. Evolutionary Biology

    The evolution of strategy in bacterial warfare via the regulation of bacteriocins and antibiotics

    Rene Niehus, Nuno M Oliveira ... Kevin R Foster
    Evolutionary game theory identifies reciprocation as a key winning strategy for warring bacteria.
    1. Ecology
    2. Microbiology and Infectious Disease

    Novel class IIb microcins show activity against Gram-negative ESKAPE and plant pathogens

    Benedikt M Mortzfeld, Shakti K Bhattarai, Vanni Bucci
    12 new class IIb microcins have been structurally identified, phylogenetically assessed, and functionally tested for their antimicrobial activity, increasing the total number of these bacteriocins to 17.
    1. Microbiology and Infectious Disease

    Exploiting CRISPR-Cas to manipulate Enterococcus faecalis populations

    Karthik Hullahalli, Marinelle Rodrigues, Kelli L Palmer
    Conflicts between CRISPR-Cas systems and antibiotic resistance plasmids can be exploited to selectively eliminate antibiotic resistance from Enterococcus faecalis populations.
    1. Microbiology and Infectious Disease

    Antimicrobials from a feline commensal bacterium inhibit skin infection by drug-resistant S. pseudintermedius

    Alan M O'Neill, Kate A Worthing ... Richard L Gallo
    The discovery and development of a feline skin commensal bacterium for bacteriotherapy against skin disease, that could benefit patients due to established low cytotoxicity, broad-spectrum antimicrobial activity and anti-inflammatory activity.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Abundant toxin-related genes in the genomes of beneficial symbionts from deep-sea hydrothermal vent mussels

    Lizbeth Sayavedra, Manuel Kleiner ... Jillian M Petersen
    Beneficial symbiotic bacteria encode an exceptional number of toxin-related genes that are all expressed by the symbionts in the host, supporting their key role in host-microbe interactions.
    1. Biochemistry and Chemical Biology

    Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease

    Silvia C Bobeica, Shi-Hui Dong ... Wilfred A van der Donk
    Structural and biochemical characterization of the protease domain of an ABC transporter demonstrates the basis for recognition of substrate leader peptides.

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