40 results found
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Competing scaffolding proteins determine capsid size during mobilization of Staphylococcus aureus pathogenicity islands

    Altaira D Dearborn et al.
    Cryo-electron microscopy and genetics show how Staphylococcus aureus pathogenicity island 1 hijacks the assembly pathway of a helper phage for its own propagation.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    An integrin/MFG-E8 shuttle loads HIV-1 viral-like particles onto follicular dendritic cells in mouse lymph node

    Chung Park, John H Kehrl
    Intravital imaging with HIV-1 viral-like particle in mouse model reveals a mechanism for HIV-1 uptake by subcapsular sinus macrophages that facilitates HIV-1 spreading tofollicular dendritic and B cells.
    1. Cancer Biology
    2. Cell Biology

    TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells

    Debjani Pal et al.
    Phenotypic diversity and cell state transition (i.e., acquisition of a CD44+/CD24- cell state or exposure to TGF-beta) can spur intra-tumor genetic heterogeneity and contribute to acquired resistance.
    1. Chromosomes and Gene Expression

    RNA Polymerase II cluster dynamics predict mRNA output in living cells

    Won-Ki Cho et al.
    Quantitative super resolution imaging, in live mammalian cells, reveals a direct relationship between protein clustering dynamics and the number of mRNA transcribed at an endogenous gene locus.
    1. Evolutionary Biology

    Antibacterial gene transfer across the tree of life

    Jason A Metcalf et al.
    Parallel horizontal gene transfer has spread a bacteriolytic gene family to all domains of life, and has bestowed a niche-transcending adaptation in recipients that must deploy antibacterial molecules to survive in a bacterial world.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanisms of opening and closing of the bacterial replicative helicase

    Jillian Chase et al.
    Analysis of the Escherichia coli DnaB helicase•bacteriophage λ helicase loader (λP) complex provides insights into helicase opening, delivery to the origin and ssDNA entry, and closing in preparation for translocation.
    1. Biochemistry and Chemical Biology

    Translation repression via modulation of the cytoplasmic poly(A)-binding protein in the inflammatory response

    Xu Zhang et al.
    The RNA-binding protein, Zfp36, which is critical for resolving inflammation, inhibits the production of proinflammatory cytokines via modulation of the cytoplasmic poly(A)-binding protein.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Dna2 nuclease-helicase structure, mechanism and regulation by Rpa

    Chun Zhou et al.
    X-ray crystallography reveals that the Dna2 nuclease-helicase contains a long tunnel through which single-stranded DNA threads, and an allosteric mechanism for displacing the DNA-binding protein Rpa that restricts cleavage to the proper polarity.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Evidence for a DNA-relay mechanism in ParABS-mediated chromosome segregation

    Hoong Chuin Lim et al.
    In vitro, in vivo and in silico evidence suggests that bacteria exploit intrinsic chromosomal fluctuations to achieve intracellular transport.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

    Timothy R Sampson et al.
    Production of an amyloid protein by bacteria within the gut microbiome can influence the pathophysiology of a mouse model of synucleinopathy.

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