132 results found
    1. Cell Biology
    2. Evolutionary Biology

    Chromatin is an ancient innovation conserved between Archaea and Eukarya

    Ron Ammar et al.
    Similarities in the way that nucleosomes are organized into chromatin in archaea and eukaryotes suggest that chromatin might have been involved in gene regulation before its role in DNA packaging evolved.
    1. Biochemistry and Chemical Biology

    Stepwise assembly of the human replicative polymerase holoenzyme

    Mark Hedglin et al.
    Fluorescence resonance energy transfer has been used to explore the interactions between DNA polymerases, sliding clamps and clamp loaders as DNA is replicated in human cells.
    1. Structural Biology and Molecular Biophysics

    Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization

    Siyang Sun et al.
    Electron cryo-microscopy has been used to determine the structure of Chikungunya virus-like particles and to provide new insights into their interactions with four different antibodies.
    1. Evolutionary Biology

    Improved use of a public good selects for the evolution of undifferentiated multicellularity

    John H Koschwanez et al.
    The ability to share resources for the benefit of all members of a group may have driven ancient organisms to evolve from a unicellular to a multicellular state.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Mechanism for priming DNA synthesis by yeast DNA Polymerase α

    Rajika L Perera et al.
    The details of how the enzyme DNA polymerase α initiates the polymerization of nucleotides in DNA replication, a critical step in the synthesis of new chromosomal DNA, have been revealed in atomic detail.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The structure of the COPII transport-vesicle coat assembled on membranes

    Giulia Zanetti et al.
    A structure of the complete, membrane bound, COPII coat solved by sub-tomogram averaging reveals the arrangement of all protein subunits on the membrane and suggests a mechanism for coating heterogeneously-shaped carriers.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

    Matthew A Cottee et al.
    Structural analyses of the centriole proteins CPAP and STIL identify domains that are critical for centriole formation and provide a structural explanation for a mutation that causes human microcephaly.
    1. Chromosomes and Gene Expression

    Direct observation of frequency modulated transcription in single cells using light activation

    Daniel R Larson et al.
    Steroid hormone receptors control the expression of their target genes through a digital on-off switch in individual cells, which leads to an analogue dose-response relationship at the level of the whole organism.
    1. Chromosomes and Gene Expression

    Engineered proteins detect spontaneous DNA breakage in human and bacterial cells

    Chandan Shee et al.
    Fluorescent derivatives of a bacteriophage protein that binds double-stranded ends can trap and label genome-destabilizing double-strand DNA breaks in bacterial and human cells, and illuminate the origins of spontaneous DNA breakage in both.
  1. DNA Damage: Proteins pinpoint double strand breaks

    Michael M Cox
    Insight
    Available as:
    • HTML
    • PDF

Refine your results by:

Type
Research categories