186 results found
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Discovery and characterization of a novel family of prokaryotic nanocompartments involved in sulfur metabolism

    Robert J Nichols et al.
    A protein-bounded organelle-like compartment from Synechococcus elongatus PCC 7942 is upregulated under sulfur starvation and contains a cysteine desulfurase cargo enzyme.
    1. Biochemistry and Chemical Biology

    Virus Engineering: ORACLE reveals a bright future to fight bacteria

    Willow Coyote-Maestas, James S Fraser
    A new way to alter the genome of bacteriophages helps produce large libraries of variants, allowing these bacteria-killing viruses to be designed to target species harmful to human health.
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    1. Biochemistry and Chemical Biology

    Mapping the functional landscape of the receptor binding domain of T7 bacteriophage by deep mutational scanning

    Phil Huss et al.
    An unbiased mutational screen decodes the molecular basis of phage receptor interactions, identifies key functional regions determining activity and host range, and demonstrates the potential for engineering therapeutic phages.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence

    Tingting Wang et al.
    The transcription factor (TF)-binding specificities of Pseudomonas aeruginosa allow us to predict virulence-associated TFs and their target genes, which will facilitate to find effective treatment and prevention for its associated diseases.
    1. Structural Biology and Molecular Biophysics

    Switch-like control of helicase processivity by single-stranded DNA binding protein

    Barbara Stekas et al.
    A single-stranded DNA binding protein stimulates helicase-mediated DNA unwinding by transiently activating a latent processivity switch in the helicase.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Genomic epidemiology of COVID-19 in care homes in the east of England

    William L Hamilton et al.
    SARS-CoV-2 can spread efficiently within care homes causing outbreaks among residents, who are at increased risk of severe disease, emphasising the importance of stringent infection control in this population.
    1. Ecology
    2. Evolutionary Biology

    Effects of domestication on the gut microbiota parallel those of human industrialization

    Aspen T Reese et al.
    Gut microbial signatures of domestication parallel those of industrialization, implicating shared ecological drivers.
    1. Microbiology and Infectious Disease

    MetaHiC phage-bacteria infection network reveals active cycling phages of the healthy human gut

    Martial Marbouty et al.
    Physical contacts of bacteria and phage genomes allow in situ exploration of underdocumented phage families in the gut.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Repeated outbreaks drive the evolution of bacteriophage communication

    Hilje M Doekes et al.
    Mathematical modelling suggests that the evolution of communication between bacterial viruses requires repeated outbreak events, and the model then predicts typical communication strategies.

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