1,595 results found
    1. Cell Biology

    In vivo identification of GTPase interactors by mitochondrial relocalization and proximity biotinylation

    Alison K Gillingham et al.
    Relocation of Rab, Ras and Rho family GTPases to the surface of mitochondria enables efficient identification of their effectors, exchange factors and GAPs by proximity biotinylation.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation

    Jamie A Macpherson et al.
    Specific residues within an enzyme integrate allosteric inputs that originate from distinct ligand-binding pockets.
    1. Genetics and Genomics
    2. Neuroscience

    Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive

    Yoonhee Ki, Chunghun Lim
    Threonine promotes sleep via down-regulation of metabotropic GABA transmission in the ellipsoid body R2 neurons that generate homeostatic sleep drive in Drosophila.
    1. Neuroscience

    Neuronal integration in the adult mouse olfactory bulb is a non-selective addition process

    Jean-Claude Platel et al.
    Adult neurogenesis in the olfactory bulb is not a turnover system but represents a lifelong neuronal addition mechanism.
    1. Neuroscience

    Sonic hedgehog signaling in astrocytes mediates cell type-specific synaptic organization

    Steven A Hill et al.
    Astrocytes modulate synaptic remodeling of developing circuits in a cell type-specific manner, with long lasting deficits in synaptic plasticity.
    1. Neuroscience

    Impact of precisely-timed inhibition of gustatory cortex on taste behavior depends on single-trial ensemble dynamics

    Narendra Mukherjee et al.
    Primary taste cortex does far more than code tastes by turning taste codes into motor commands via population dynamics.
    1. Cell Biology

    The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition

    Danielle DiTirro et al.
    A Tubby protein regulates ciliary membrane morphology and phosphoinositide composition in a context-dependent manner.
    1. Physics of Living Systems

    A microfluidic device for inferring metabolic landscapes in yeast monolayer colonies

    Zoran S Marinkovic et al.
    Metabolic gradients underlie gene expression patterns within spatially controlled expanding 2D microbial colonies.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Genetic interactions of G-quadruplexes in humans

    Katherine G Zyner et al.
    For the first time, the spectrum of genes and pathways interacting with alternative DNA structures called G-quadruplexes in humans is revealed highlighting new possibilities for the pursuit of cancer therapies.
    1. Ecology

    Comment on 'Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age'

    Philip Dammann et al.
    We are writing to comment on the article by Ruby et al., 2018 about aging in naked mole-rats.

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