RNA-binding proteins use both translational activation and repression of key molecular determinants to post-mitotically sculpt the identity and connectivity of developing mouse neocortex in an area-specific manner.

Boundary:boundary pairing interactions drive TAD formation in Drosophila.

tRNA Q34 modification impacts tyrosine codon decoding and leads to proteome reprogramming in response to antibiotic stress in Vibrio cholerae.

CryoEM reveals the structure of a two-component archaeal S-layer, which sheds new light on archaeal cell biology.

Multi-level massively parallel reporter assays (H3K27ac, ATAC and short tiles) in a panel of melanoma cell lines, together with a deep learning model, reveal location, multiplicity and grammar of subtype specific enhancers.

IL-27 exerts differential activation of STAT1 and STAT3 via IL-27Ra and GP130, respectively, leading to a kinetic decoupling of its gene expression program, which contributes to tune its immuno-modulatory activities.

Context factors such as experimental task and model parameterization can significantly impact modeling results, such that across tasks, the same participants show different fitted parameter values, and parameters capture different cognitive processes across tasks.

GTP binding induces rearrangement of S-OPA1 assembly on membrane and thus triggers membrane remodeling with reduced curvature.

SINE RNAs are implicated in amyloid beta molecular pathology in hippocampus.

The loss of p53 in bone cells activates critical signaling pathways; these are also essential in bone cancer.