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    1. Neuroscience

    Altered basal ganglia output during self-restraint

    Bon-Mi Gu, Joshua D Berke
    Rats are slower to initiate actions when these actions may need to be cancelled, and this slowing is associated with increased and more variable neural firing in the substantia nigra pars reticulata.
    1. Cell Biology

    Centriolar remodeling underlies basal body maturation during ciliogenesis in Caenorhabditis elegans

    Inna V Nechipurenko, Cristina Berciu ... Daniela Nicastro
    Building on previous work (Doroquez et al., 2014), it is shown that the centriole core of the basal body degenerates, but the outer wall remodels to template the ciliary axoneme in a subset of C. elegans ciliated sensory neurons.
    1. Neuroscience

    The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition

    Beatriz Alvarez-Castelao, Susanne tom Dieck ... Erin M Schuman
    In neurons, inhibition of the proteasome results in feedback inhibition of protein synthesis, mediated by heme-regulated kinase 1, which is optimized to act as both a sensor and an effector.
    1. Neuroscience

    The amygdala instructs insular feedback for affective learning

    Dominic Kargl, Joanna Kaczanowska ... Wulf Haubensak
    Hierarchical information flow in a cortico-limbic loop between the insular cortex, central amygdala and the cholinergic basal forebrain links bodily states with environmental stimuli to guide fear and reward behavior.
    1. Evolutionary Biology
    2. Neuroscience

    The visual pigment xenopsin is widespread in protostome eyes and impacts the view on eye evolution

    Clemens Christoph Döring, Suman Kumar ... Harald Hausen
    The employment of xenopsin in ciliary and mixed microvillar/ciliary eye sensory cells in several protostome animals suggests high evolutionary plasticity of photoreceptors.
    1. Computational and Systems Biology
    2. Neuroscience

    A cholinergic feedback circuit to regulate striatal population uncertainty and optimize reinforcement learning

    Nicholas T Franklin, Michael J Frank
    Computational modeling suggests that feedback between striatal cholinergic neurons and spiny neurons dynamically adjusts learning rates to optimize behavior in a variable world.
    1. Cell Biology

    H+- and Na+- elicited rapid changes of the microtubule cytoskeleton in the biflagellated green alga Chlamydomonas

    Yi Liu, Mike Visetsouk ... Pinfen Yang
    Acidification and salt, which are two major stresses caused by environmental changes, swiftly and drastically alter the microtubule system in green algae and likely many other organisms.
    1. Developmental Biology

    A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development

    Kerstin Hasenpusch-Theil, Christine Laclef ... Thomas Theil
    Primary-cilia-mediated processing of the Gli3 transcription factor enables the formation of subtypes of projection neurons in appropriate numbers during the development of the cerebral cortex.
    1. Neuroscience

    An insect-like mushroom body in a crustacean brain

    Gabriella Hannah Wolff, Hanne Halkinrud Thoen ... Nicholas James Strausfeld
    An insect-like mushroom body in one group of crustaceans, the mantis shrimps (Stomatopoda), suggests either an ancient origin of this center and its reduction and loss in other crustaceans, or an extraordinary example of convergent evolution with the insect mushroom body.
    1. Cell Biology

    Damage-induced basal epithelial cell migration modulates the spatial organization of redox signaling and sensory neuron regeneration

    Alexandra M Fister, Adam Horn ... Anna Huttenlocher
    Isotonic treatment limits keratinocyte movement, spatially restricts reactive oxygen species production, and rescues sensory neuron function after thermal injury.