300 results found
    1. Neuroscience

    miR-9 regulates basal ganglia-dependent developmental vocal learning and adult vocal performance in songbirds

    Zhimin Shi et al.
    Gene manipulation combined with behavior analysis reveals a role of miR-9 in modulating basal-ganglia-dependent developmental vocal learning and adult vocal performance via regulating the FOXP1/FOXP2 gene network and dopamine signaling in songbirds.
    1. Neuroscience

    The inhibitory microcircuit of the substantia nigra provides feedback gain control of the basal ganglia output

    Jennifer Brown et al.
    Negative feedback signals within the substantia nigra regulate the output of the basal ganglia, with implications for disorders such as Parkinson's disease.
    1. Neuroscience

    Subthalamic, not striatal, activity correlates with basal ganglia downstream activity in normal and parkinsonian monkeys

    Marc Deffains et al.
    The spiking activity of the subthalamic nucleus, rather than the activity of striatal projection neurons, orchestrates basal ganglia downstream activity and output commands in health and Parkinson’s disease.
    1. Computational and Systems Biology
    2. Neuroscience

    Competing basal ganglia pathways determine the difference between stopping and deciding not to go

    Kyle Dunovan et al.
    A model based on the architecture of basal ganglia and validated with behavior and neuroimaging distinguishes mechanisms of action cancellation from no-go decisions.
    1. Neuroscience

    Neural activity in cortico-basal ganglia circuits of juvenile songbirds encodes performance during goal-directed learning

    Jennifer M Achiro et al.
    Activity in cortico-basal ganglia circuits of juvenile songbirds reflects evaluative signals necessary for comparing self-generated behavior to a goal representation during skill learning.
    1. Neuroscience

    Basal ganglia output reflects internally-specified movements

    Mario J Lintz, Gidon Felsen
    The basal ganglia may preferentially influence movements based on internal goals rather than those guided by external stimuli.
    1. Neuroscience

    Decoding gripping force based on local field potentials recorded from subthalamic nucleus in humans

    Huiling Tan et al.
    Patterns of coordinated activity in the basal ganglia predict how much force we will use to grip objects, suggesting that individuals with paralysis may ultimately be able to use these signals to control graded responses in robotic devices.
    1. Neuroscience

    A role for cerebellum in the hereditary dystonia DYT1

    Rachel Fremont et al.
    The most common inherited dystonia, DYT1, is likely caused primarily by the dysfunction of the cerebellum rather than the basal ganglia.
    1. Neuroscience

    The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons

    Andrew Lutas et al.
    Basal ganglia output neurons use the NALCN leak channel to maintain their characteristic tonic firing, and this channel is important for the modulation of firing by metabolic or receptor-mediated signals.
    1. Neuroscience

    Pedunculopontine glutamatergic neurons control spike patterning in substantia nigra dopaminergic neurons

    Daniel J Galtieri et al.
    Pedunculopontine neurons can evoke burst spiking in substantia nigra dopaminergic neurons without engaging a subtype of glutamate receptor previously thought to be necessary for this spiking mode.

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