372 results found
    1. Developmental Biology
    2. Neuroscience

    A Gata3–Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing

    Wei-Ming Yu, Jessica M Appler ... Lisa V Goodrich
    Genetic studies in mice identify the transcription factor MafB as a potent regulator of specific features of the synapses underlying hearing.
    1. Neuroscience

    Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons

    Zhong L Hua, Philip M Smallwood, Jeremy Nathans
    The signaling molecule Frizzled3 plays a part in the development of the nervous system by controlling the ability of motor neurons to form connections with distant target muscles.
    1. Neuroscience

    The structure and organization of lanceolate mechanosensory complexes at mouse hair follicles

    Lishi Li, David D Ginty
    Close examination of lanceolate mechanosensory complexes has revealed clues about the ways that sensory nerves detect the movement of hairs and shown than terminal Schwann cells are needed to maintain and regenerate these intricate structures.
    1. Neuroscience

    Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis

    Nicolas X Tritsch, Won-Jong Oh ... Bernardo L Sabatini
    The molecular mechanisms by which midbrain dopamine neurons acquire the inhibitory neurotransmitter GABA for synaptic release are revealed.
    1. Neuroscience

    Caenorhabditis elegans male sensory-motor neurons and dopaminergic support cells couple ejaculation and post-ejaculatory behaviors

    Brigitte LeBoeuf, Paola Correa ... L René García
    In nematode worms, the length of the male refractory period–the time between matings–is regulated by multiple transmitters including dopamine, which both promotes ejaculation and reduces the activity of males post-copulation.
    1. Neuroscience

    A role for descending auditory cortical projections in songbird vocal learning

    Yael Mandelblat-Cerf, Liora Las ... Michale S Fee
    Midbrain dopaminergic neurons and a cortex-like structure called the arcopallium form part of a circuit that enables young songbirds to compare their own song with a template stored in memory, and use any discrepancies to improve their performance.
    1. Neuroscience

    Homeostatic reinforcement learning for integrating reward collection and physiological stability

    Mehdi Keramati, Boris Gutkin
    A mathematical model built around the assumption that the desire to maintain internal homeostasis drives the behavior of animals, by affecting their learning processes, can explain many real-world behaviors, including some that might otherwise appear irrational.
    1. Neuroscience

    A neural circuit mechanism for regulating vocal variability during song learning in zebra finches

    Jonathan Garst-Orozco, Baktash Babadi, Bence P Ölveczky
    By demonstrating song learning-related synaptic strengthening and pruning in the vocal control circuits of songbirds, and showing how such changes can reduce the sensitivity of the circuit to ‘noisy’ inputs, a simple neural circuit mechanism for regulating motor variability during motor skill learning is identified.
    1. Cell Biology
    2. Neuroscience

    Neuron-wide RNA transport combines with netrin-mediated local translation to spatially regulate the synaptic proteome

    Sangmok Kim, Kelsey C Martin
    The spatial regulation of gene expression within neurons occurs primarily at the level of local translation rather than by stimulus-induced RNA targeting from nucleus to synapse.
    1. Developmental Biology
    Ciona intestinalis illustration

    The Natural History of Model Organisms: An organismal perspective on C. intestinalis development, origins and diversification

    Matthew J Kourakis, William C Smith
    The life cycle and morphology of the sea squirt Ciona intestinalis shed light on vertebrate evolution.

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