The naturally occurring biologics, FLO and HC-HA/PTX3, derived from human birth tissues, may be developed as a much-needed non-opioid therapy for post-surgical pain treatment, leveraging robust neuronal mechanisms.
John P Grogan, Matthias Raemaekers ... Sanjay G Manohar
Muscarinic antagonism is causally involved in motivation and incentivisation in healthy human participants, partially mediated via preparatory neural signatures, with implications for cholinergic treatment of Parkinson's disease.