Whole-brain activity imaging in larval zebrafish reveals brain regions that influence patterns of spontaneous movement to increase local exploration efficiency.
Myelin-associated inhibitors and chondroitin sulfate proteoglycans are not the primary mechanism stopping sensory axons regenerating into the spinal cord, although their removal can markedly enhance regeneration when combined with an intervention that elevates axon growth capacity sufficiently robustly.
Alexandra Bova, Matt Gaidica ... Daniel K Leventhal
Dopamine signaling gradually causes long-lasting changes in fine motor coordination that can later be activated by acute changes in dopamine neuron activity.
Humans can rapidly build a new controller when learning continuous movement tasks and can flexibly integrate this process with adaptation of an existing controller.
Tuomo Mäki-Marttunen, Nicolangelo Iannella ... Kim T Blackwell
Biochemically detailed modelling of pathways leading to post-synaptic plasticity reveals the dependence of neocortical LTP/LTD on the availability of different proteins and stimulation patterns.
Polyglutamine expansion in mutant huntingtin disrupts a novel transcription-coupled DNA repair complex, providing an undescribed mechanism of neuronal toxicity and degeneration in Huntington's disease.
Oleg Tolstenkov, Petrus Van der Auwera ... Alexander Gottschalk
The 'missing' class of Caenorhabditis elegans excitatory motor neurons, AS, contribute to propagation and coordination of body waves, integrating information from, and feeding back to premotor interneurons byelectrical signaling.