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    1. Neuroscience

    Brain-wide mapping of neural activity controlling zebrafish exploratory locomotion

    Timothy W Dunn, Yu Mu ... Misha B Ahrens
    Whole-brain activity imaging in larval zebrafish reveals brain regions that influence patterns of spontaneous movement to increase local exploration efficiency.
    1. Neuroscience

    The connectome of the adult Drosophila mushroom body provides insights into function

    Feng Li, Jack W Lindsey ... Gerald M Rubin
    Analysis of neuronal circuit architecture provides mechanistic insights into what an adult fly can learn, remember, and use to guide its behavior.
    1. Neuroscience

    Co-targeting myelin inhibitors and CSPGs markedly enhances regeneration of GDNF-stimulated, but not conditioning-lesioned, sensory axons into the spinal cord

    Jinbin Zhai, Hyukmin Kim ... Young-Jin Son
    Myelin-associated inhibitors and chondroitin sulfate proteoglycans are not the primary mechanism stopping sensory axons regenerating into the spinal cord, although their removal can markedly enhance regeneration when combined with an intervention that elevates axon growth capacity sufficiently robustly.
    1. Cell Biology
    2. Neuroscience

    Parvalbumin interneuron ErbB4 controls ongoing network oscillations and olfactory behaviors in mice

    Bin Hu, Chi Geng ... Xiao-Yu Hou
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Precisely timed dopamine signals establish distinct kinematic representations of skilled movements

    Alexandra Bova, Matt Gaidica ... Daniel K Leventhal
    Dopamine signaling gradually causes long-lasting changes in fine motor coordination that can later be activated by acute changes in dopamine neuron activity.
    1. Neuroscience

    De novo learning versus adaptation of continuous control in a manual tracking task

    Christopher S Yang, Noah J Cowan, Adrian M Haith
    Humans can rapidly build a new controller when learning continuous movement tasks and can flexibly integrate this process with adaptation of an existing controller.
    1. Computational and Systems Biology
    2. Neuroscience

    A unified computational model for cortical post-synaptic plasticity

    Tuomo Mäki-Marttunen, Nicolangelo Iannella ... Kim T Blackwell
    Biochemically detailed modelling of pathways leading to post-synaptic plasticity reveals the dependence of neocortical LTP/LTD on the availability of different proteins and stimulation patterns.
    1. Neuroscience

    Local, calcium- and reward-based synaptic learning rule that enhances dendritic nonlinearities can solve the nonlinear feature binding problem

    Zahra Khodadadi, Daniel Trpevski ... Jeanette Hellgren Kotaleski
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

    Rui Gao, Anirban Chakraborty ... Partha S Sarkar
    Polyglutamine expansion in mutant huntingtin disrupts a novel transcription-coupled DNA repair complex, providing an undescribed mechanism of neuronal toxicity and degeneration in Huntington's disease.
    1. Neuroscience

    Functionally asymmetric motor neurons contribute to coordinating locomotion of Caenorhabditis elegans

    Oleg Tolstenkov, Petrus Van der Auwera ... Alexander Gottschalk
    The 'missing' class of Caenorhabditis elegans excitatory motor neurons, AS, contribute to propagation and coordination of body waves, integrating information from, and feeding back to premotor interneurons byelectrical signaling.