427 results found
    1. Neuroscience

    Learning: The cerebellum influences vocal timing

    Court Hull
    We are starting to understand how the cerebellum contributes to vocal learning in songbirds.
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    1. Neuroscience

    miR-9 regulates basal ganglia-dependent developmental vocal learning and adult vocal performance in songbirds

    Zhimin Shi et al.
    Gene manipulation combined with behavior analysis reveals a role of miR-9 in modulating basal-ganglia-dependent developmental vocal learning and adult vocal performance via regulating the FOXP1/FOXP2 gene network and dopamine signaling in songbirds.
    1. Neuroscience

    The effects of chloride dynamics on substantia nigra pars reticulata responses to pallidal and striatal inputs

    Ryan S Phillips et al.
    The effects of chloride homeostasis can explain diverse responses of basal ganglia output neurons to putatively inhibitory inputs and may tune these neurons' synchrony, oscillations and behavior in decision-making scenarios.
    1. Neuroscience

    Different neuronal populations mediate inflammatory pain analgesia by exogenous and endogenous opioids

    Xin-Yan Zhang et al.
    Exogenous opioid analgesia is mediated by MORs expressed in glutamatergic neurons, whereas endogenous opioid analgesia is mediated by MORs expressed in GABAergic neurons.
    1. Structural Biology and Molecular Biophysics

    Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling

    Naotaka Tsutsumi et al.
    Cryo-EM structure of monomeric human Frizzled5 was determined with a universal fiducial antibody at 3.7 Å overall resolution, which supports a simple Fzd/LRP6 heterodimerization mechanism of canonical Wnt/β-catenin signaling.
    1. Neuroscience

    Gradients in the biophysical properties of neonatal auditory neurons align with synaptic contact position and the intensity coding map of inner hair cells

    Alexander L Markowitz, Radha Kalluri
    The biophysical diversity that is intrinsic to spiral ganglion neurons emerges as spatial gradients during early post-natal development and endures through subsequent maturation to likely contribute to sound intensity coding.
    1. Developmental Biology
    2. Neuroscience

    Revisiting the role of Dcc in visual system development with a novel eye clearing method

    Robin J Vigouroux et al.
    A new eye-specific Dcc mutant combined with an improved clearing protocol for the eye and brain (EyeDISCO) reveals the requirement of the receptor Dcc for retinal development and maintenance.
    1. Neuroscience

    Movement-related coupling of human subthalamic nucleus spikes to cortical gamma

    Petra Fischer et al.
    When coupling between STN spikes and cortical gamma oscillations was strong, subsequent movement was initiated earlier, independent of changes in mean firing rates, demonstrating the importance of relative spike timing.
    1. Neuroscience

    In vivo assessment of the neural substrate linked with vocal imitation accuracy

    Julie Hamaide et al.
    Song learning accuracy can be predicted and traced in the structural properties of the brains of juvenile male zebra finches already at 20 days post-hatching.
    1. Developmental Biology

    Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse

    Céline Portal et al.
    Primary cilia of neural crest-derived cells mediate Indian hedgehog-induced signal transduction in the periocular mesenchyme and are required for normal anterior segment development.

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