491 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Dopamine role in learning and action inference

    Rafal Bogacz
    A mathematical model describes the function of dopaminergic neurons in both learning and action planning.
    1. Neuroscience

    Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo

    Jui-Yi Hsieh et al.
    Electrophysiological analysis and imaging in live zebrafish reveal that infant- and adult-onset SCA13 mutations have distinct effects on the electrical activity, development, and survival of cerebellar Purkinje cells.
    1. Neuroscience

    Shared and specific signatures of locomotor ataxia in mutant mice

    Ana S Machado et al.
    LocoMouse analysis of severely ataxic reeler mutant mice reveals fundamental features of locomotor ataxia and provides a roadmap for linking high-dimensional behavioral phenotyping to alterations in underlying neural circuits.
    1. Human Biology and Medicine
    2. Neuroscience

    Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain

    David Cabañero et al.
    Operant drug self-administration in a mouse model of neuropathic pain reveals pain-relieving effects of a cannabinoid CB2 receptor agonist that are mediated through CB2 receptors of neurons and lymphocytes.
    1. Neuroscience

    Alterations in the intrinsic properties of striatal cholinergic interneurons after dopamine lesion and chronic L-DOPA

    Se Joon Choi et al.
    HCN and SK channel currents in striatal cholinergic neurons are decreased with dopamine loss, but only HCN is restored by chronic L-DOPA and SK abnormality persists in dyskinesia.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    New insights into the mechanism of dynein motor regulation by lissencephaly-1

    Steven M Markus et al.
    The role of LIS1 in dynein-mediated transport in various biological contexts is reviewed with a focus on recent studies that revealed a new mechanism by which LIS1 functions.
    1. Neuroscience

    Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region-specific manner

    Adam J Granger et al.
    Most ChAT-expressing interneurons are a subset VIP+ interneurons that differentially release GABA and acetylcholine onto different post-synaptic targets, while a separate population of non-VIP ChAT+ neurons release acetylcholine in mPFC.
    1. Neuroscience

    Gradients in the biophysical properties of neonatal auditory neurons align with synaptic contact position and the intensity coding map of inner hair cells

    Alexander L Markowitz, Radha Kalluri
    The biophysical diversity that is intrinsic to spiral ganglion neurons emerges as spatial gradients during early post-natal development and endures through subsequent maturation to likely contribute to sound intensity coding.
    1. Cell Biology

    Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface

    Abril Angélica Escamilla-Ayala et al.
    Super-resolution microscopy sets a new strategy to comprehend the membrane organization of γ-secretase at single complex resolution identifying nanodomain associations and its diffusion in situ in the living membrane.
    1. Neuroscience

    Globus pallidus dynamics reveal covert strategies for behavioral inhibition

    Bon-Mi Gu et al.
    Rats can pre-position the state of their basal ganglia neural networks to adaptively influence their subsequent response to a Go signal.

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