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    1. Cell Biology
    2. Neuroscience

    PTRN-1, a microtubule minus end-binding CAMSAP homolog, promotes microtubule function in Caenorhabditis elegans neurons

    Claire E Richardson, Kerri A Spilker ... Kang Shen
    The protein PTRN-1 anchors microtubules in neuronal branches to promote proper neuron morphology and function in Caenorhabditis elegans.
    1. Neuroscience

    Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons

    Silvia Ripamonti, Mateusz C Ambrozkiewicz ... JeongSeop Rhee
    Perturbation of oxytocin signaling causes alterations that may be causally involved in the etiology of oxytocin-related neurobehavioral disorders.
    1. Computational and Systems Biology
    2. Medicine

    NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism

    Homa MohammadiPeyhani, Anush Chiappino-Pepe ... Vassily Hatzimanikatis
    NICEdrug.ch is a resource allowing systematic and large-scale computational analysis of drug biochemistry, enzymatic targets, and toxicity in the context of cellular metabolism.
    1. Microbiology and Infectious Disease

    Interplay between acetylation and ubiquitination of imitation switch chromatin remodeler Isw1 confers multidrug resistance in Cryptococcus neoformans

    Yang Meng, Yue Ni ... Chen Ding
    Isw1 acts as a master regulator in modulating the expression of drug-resistance genes, and this regulatory mechanism is dependent on the interaction of Isw1 acetylation and ubiquitination.
    1. Cell Biology
    2. Developmental Biology

    A transcriptomics resource reveals a transcriptional transition during ordered sarcomere morphogenesis in flight muscle

    Maria L Spletter, Christiane Barz ... Frank Schnorrer
    A developmental transcriptomics resource from Drosophila flight muscles quantifies the transcriptional dynamics during muscle morphogenesis and identifies three ordered phases of sarcomere morphogenesis.
    1. Developmental Biology

    Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally

    Jadiel A Wasson, Ashley K Simon ... David J Katz
    Epigenetic reprogramming by LSD1/KDM1A acts at fertilization in mice to enable embryogenesis and prevent behavioural abnormalities.
    1. Developmental Biology
    2. Evolutionary Biology

    Conservation of peripheral nervous system formation mechanisms in divergent ascidian embryos

    Joshua F Coulcher, Agnès Roure ... Sébastien Darras
    Developmental regulatory mechanisms for peripheral nervous system formation appear to be conserved in ascidians despite extensive genomic divergence after 390 MY of separate evolution.
    1. Developmental Biology

    Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells

    Di Peng, Koji Ando ... Katarzyna Koltowska
    Spatio-temporal analysis using live imaging in zebrafish reveals mural cells as a source of pro-lymphangiogenic factors including chemokine and growth factor signalling, necessary for robust lymphatic endothelial cell migration and survival.
    1. Microbiology and Infectious Disease

    A modified BCG with depletion of enzymes associated with peptidoglycan amidation induces enhanced protection against tuberculosis in mice

    Moagi Tube Shaku, Peter K Um ... Bavesh D Kana
    The new vaccine candidate for tuberculosis displays superior protection against disease when compared the currently available vaccine, and can potentially provide new options for global childhood vaccination programs.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Midkine is a dual regulator of wound epidermis development and inflammation during the initiation of limb regeneration

    Stephanie L Tsai, Clara Baselga-Garriga, Douglas A Melton
    Elucidation of the molecular basis of early wound epidermis dependence during salamander limb regeneration reveals midkine as a key modulator of wound epidermis development and wound-healing resolution.