Soledad A Camolotto, Shrivatsav Pattabiraman ... Eric L Snyder
Lineage specifiers FoxA1 and FoxA2 control lung cancer growth and identity by activating gastric differentiation and suppressing squamous cell carcinoma transdifferentiation.
Unraveling the ultrafast polar tube ejection in microsporidia reveals extreme cellular hydraulics, providing a data-driven model for infectious cargo transport, with implications for physical approaches to understanding microsporidia transmission.
The ERK8 kinase blocks the export of glycosyl-tranferases from the Golgi to the endoplasmic reticulum, and thus subsequent O-glycosylation of proteins that otherwise enhance cell motility and tissue invasion.
Characterization of Tnc as a selective integrin ligand at the Drosophila NMJ allows for unprecedented insights into our understanding of extracellular matrix/integrin interactions at synaptic locations and reveals novel, distinct presynaptic and postsynaptic integrin functions.
Klaus Bonazza, Roxana E Iacob ... Timothy A Springer
Both the polypeptide and attached O-glycans N-terminal to the A1 domain in von Willebrand factor lower its affinity for its ligand GPIbα on platelets, its stability, and structural dynamics and decrease population of a high-affinity, intermediate state in unfolding.
The heterogeneity in molecule and function of three main cell types of smooth muscle cells, endothelial cells, and fibroblasts from both different anatomical sites of pig skin was comprehensively exposited.
RNAseq profiles of female Aedes body parts, gut regions, and blood-fed guts provide insight into the anatomical patterning of immune and digestive function, and demonstrate the sequential induction of multiple peptidase cohorts over the course of blood meal digestion.
