42 results found
    1. Neuroscience

    Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae

    Wenxuan He, David Kemp, Tianying Ren
    Heterodyne low-coherence interferometry demonstrates that the latency of the sound-induced reticular lamina vibration is significantly greater than that of the basilar membrane vibration in living gerbil cochleae.
    1. Neuroscience
    2. Physics of Living Systems

    The frequency limit of outer hair cell motility measured in vivo

    Anna Vavakou, Nigel P Cooper, Marcel van der Heijden
    The cells in our inner ear commonly believed to provide fast mechanical feedback are too sluggish to follow the vibrations evoked by high-frequency sounds.
    1. Genetics and Genomics
    2. Medicine

    PTPRG is an ischemia risk locus essential for HCO3-dependent regulation of endothelial function and tissue perfusion

    Kristoffer B Hansen, Christian Staehr ... Ebbe Boedtkjer
    HCO3-sensitive regulation of endothelium-dependent vasorelaxation by receptor-type tyrosine-protein phosphatase RPTPγ provides a novel mechanism for acid-base-mediated coordination of cerebrovascular perfusion during increased local metabolism and for protection against ischemia.
    1. Neuroscience

    Subcellular analysis of pigeon hair cells implicates vesicular trafficking in cuticulosome formation and maintenance

    Simon Nimpf, Erich Pascal Malkemper ... David A Keays
    Cuticulosomes are organelles found in the hair cells of birds that are composed of ferritin nanoparticles, form rapidly after hatching by the fusion of vesicular structures, and may play an indirect role in magnetic sensation.
    1. Neuroscience
    2. Physics of Living Systems

    Stiffness and tension gradients of the hair cell’s tip-link complex in the mammalian cochlea

    Mélanie Tobin, Atitheb Chaiyasitdhi ... Pascal Martin
    The tip-link complex of the hair cell is mechanically tuned along the tonotopic axis of the cochlea.
    1. Neuroscience

    Outer hair cells stir cochlear fluids

    Choongheon Lee, Mohammad Shokrian ... Jong-Hoon Nam
    Inner-ear drug delivery experiments show that the fluids in the cochlea circulate due to the peristaltic action of motile auditory receptor cells.
    1. Cell Biology
    2. Developmental Biology

    Gradients of glucose metabolism regulate morphogen signalling required for specifying tonotopic organisation in the chicken cochlea

    James DB O'Sullivan, Thomas S Blacker ... Zoe F Mann
    Distinct metabolic states coupled with differing morphogen levels regulate HC morphology along the tonotopic axis of the developing chick auditory organ.
    1. Developmental Biology

    Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis

    Benoit Vanhollebeke, Oliver A Stone ... Didier YR Stainier
    The membrane proteins Reck and Gpr124 are integral components of a novel Wnt7a/Wnt7b-specific signaling complex, and there is a distinctive requirement for Wnt/β-catenin signaling in tip cells during angiogenesis in the central nervous system.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Microbiota regulates visceral pain in the mouse

    Pauline Luczynski, Monica Tramullas ... John F Cryan
    Determining that microbiota-deficient mice have increased visceral pain, which can be reversed by restoring microbiota, may lead to novel microbial-based strategies for disorders associated with visceral pain.
    1. Cell Biology
    2. Neuroscience

    TMC1 is an essential component of a leak channel that modulates tonotopy and excitability of auditory hair cells in mice

    Shuang Liu, Shufeng Wang ... Wei Xiong
    Other than its function in mechanotransduction, TMC1 is indispensable for action potential firing of auditory hair cells by mediating a leak conductance that alters tonotopically along the cochlea coil.

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