Heterodyne low-coherence interferometry demonstrates that the latency of the sound-induced reticular lamina vibration is significantly greater than that of the basilar membrane vibration in living gerbil cochleae.
Anna Vavakou, Nigel P Cooper, Marcel van der Heijden
The cells in our inner ear commonly believed to provide fast mechanical feedback are too sluggish to follow the vibrations evoked by high-frequency sounds.
Kristoffer B Hansen, Christian Staehr ... Ebbe Boedtkjer
HCO3–-sensitive regulation of endothelium-dependent vasorelaxation by receptor-type tyrosine-protein phosphatase RPTPγ provides a novel mechanism for acid-base-mediated coordination of cerebrovascular perfusion during increased local metabolism and for protection against ischemia.
Simon Nimpf, Erich Pascal Malkemper ... David A Keays
Cuticulosomes are organelles found in the hair cells of birds that are composed of ferritin nanoparticles, form rapidly after hatching by the fusion of vesicular structures, and may play an indirect role in magnetic sensation.
James DB O'Sullivan, Thomas S Blacker ... Zoe F Mann
Distinct metabolic states coupled with differing morphogen levels regulate HC morphology along the tonotopic axis of the developing chick auditory organ.
Benoit Vanhollebeke, Oliver A Stone ... Didier YR Stainier
The membrane proteins Reck and Gpr124 are integral components of a novel Wnt7a/Wnt7b-specific signaling complex, and there is a distinctive requirement for Wnt/β-catenin signaling in tip cells during angiogenesis in the central nervous system.
Pauline Luczynski, Monica Tramullas ... John F Cryan
Determining that microbiota-deficient mice have increased visceral pain, which can be reversed by restoring microbiota, may lead to novel microbial-based strategies for disorders associated with visceral pain.
Other than its function in mechanotransduction, TMC1 is indispensable for action potential firing of auditory hair cells by mediating a leak conductance that alters tonotopically along the cochlea coil.