Tissue microarrays, a high-throughout approach to quantifying biomarkers used in hundreds of cancer studies every year, are susceptible to batch effects that can alter results but that are readily addressable.

Whereas theories of ecological diversity mostly consider continuously supplied nutrients, a seasonal model uncovers a general mechanism that controls diversity and reconciles conflicting experimental findings.

CytofRUV is a computational algorithm that effectively enables batch effect reduction in multiple CyTOF batches with an adaptable normalisation method and an R-Shiny application with diagnostics plots.

Investigation of dynamic gene regulation across cell types and environments reveals new GxE regulatory loci that are important for disease.

Metabolic gradients underlie gene expression patterns within spatially controlled expanding 2D microbial colonies.

Automated liquid handling, whole mount staining, and clearing allow unbiased 3D quantitation of cell markers in human neural organoids with diameters of up to 1 mm at the single-cell level.

Endothelial dysfunction due to cardiovascular disease risk factors explained by cardiac endothelial cell transcriptome remodelling.

A novel algorithm, consensus non-negative matrix factorization (cNMF), accurately identifies gene expression programs underlying cell-type identity and cellular activities from single-cell RNA-Seq data.

Embryonic gene expression is strongly influenced by maternal genetic variation and by embryonic variation that acts in cis but not in trans.

The ovarian immune system ages while coping with the two main challenges of the aging ovary before menopause, the inflammatory stimulations due to repeated cycles and the increasing need for clearance of accumulating atretic follicles.