4 results found
    1. Cancer Biology

    Extent, impact, and mitigation of batch effects in tumor biomarker studies using tissue microarrays

    Konrad H Stopsack, Svitlana Tyekucheva ... Lorelei A Mucci
    Tissue microarrays, a high-throughout approach to quantifying biomarkers used in hundreds of cancer studies every year, are susceptible to batch effects that can alter results but that are readily addressable.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Fungal effector Ecp6 outcompetes host immune receptor for chitin binding through intrachain LysM dimerization

    Andrea Sánchez-Vallet, Raspudin Saleem-Batcha ... Jeroen R Mesters
    Structural and biochemical analysis of a protein called Ecp6, which is produced by a tomato fungus, reveals how the protein prevents plants from launching an immune response to the chitin in fungal cell walls.
    1. Plant Biology

    The kinase LYK5 is a major chitin receptor in Arabidopsis and forms a chitin-induced complex with related kinase CERK1

    Yangrong Cao, Yan Liang ... Gary Stacey
    The chitin-triggered immune response is mediated by a LYK5 and CERK1 receptor complex in Arabidopsis.
    1. Microbiology and Infectious Disease

    Pathogen clonal expansion underlies multiorgan dissemination and organ-specific outcomes during murine systemic infection

    Karthik Hullahalli, Matthew K Waldor
    During Escherichia coli systemic infection, the replication of a minuscule fraction of the inoculum drives organ-specific clearance failures, systemic dissemination, and stochastic infection outcomes.

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