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A phenome-wide Mendelian randomisation analysis revealed a causal link between age-related macular degeneration and a number of lipid, complement, immune cell, and serum protein traits, highlighting potential treatment targets.

The role host and vector species play in pathogen transmission cycles is best quantified by integrating species' physiological and ecological competence.

A statistical approach for predicting non-active site residues responsible for allostery, cooperativity, or other subtle but functionally important interactions is described and applied to various protein families.

An analysis of author contribution statements in a large number of published papers reveals biases in the career trajectories of scientists.

A demonstration of the power of routine case data and statistical modelling to guide the allocation of anti-malarial interventions in a resource-constrained setting.

Integrating the sinh-arcsinh distribution into a distributional regression framework allows us to produce precise, local estimates of sexual age-mixing, facilitating more accurate modelling of sexually transmitted disease dynamics.

µGUIDE is a Bayesian framework that leverages simulation-based inference to efficiently estimate posterior distributions of any forward model parameters, allowing for uncertainty quantification and degeneracy detection.

A combined theoretical and experimental study revealed the mechanistic and structural basis of mutational effects on allostery and provided insights into the intrinsic connection of intra- and inter-domain properties.

Human tilt estimation in natural scenes is predicted by an image-computable Bayes optimal model that is grounded in the statistics of natural images and scenes.

A subset of genes in the mouse brain show dynamically regulated and unequal expression of maternally and paternally derived variants, with implications for brain development and function.