68 results found
    1. Microbiology and Infectious Disease

    Microbiota functional activity biosensors for characterizing nutrient metabolism in vivo

    Darryl A Wesener et al.
    A method has been developed to characterize the expressed biochemical activities of gut microbial communities using retrievable, microscopic, fluorescent-labeled glass beads containing chemically bound surface biomolecules.
    1. Cell Biology

    Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis

    Hiromi Imamura et al.
    Cleavage of pannexin-1 channel by caspases facilitates the loss of intracellular ATP level and attenuates glycolytic metabolism of apoptotic cells.
    1. Neuroscience

    Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration

    Xinde Zheng et al.
    Rapamycin treatment inhibits mTOR activity and preserves ATP levels in neurons derived from induced pluripotent stem cells from a maternally inherited Leigh syndrome patient.
    1. Immunology and Inflammation

    Intravital quantification reveals dynamic calcium concentration changes across B cell differentiation stages

    Carolin Ulbricht et al.
    Heterogeneity in cytoplasmic calcium concentration alongside B cell activation and differentiation is measured intravitally using an interdisciplinary imaging approach and novel numerical analysis.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Neuroprotective effects of TRPA1 channels in the cerebral endothelium following ischemic stroke

    Paulo Wagner Pires, Scott Earley
    Acute hypoxia activates TRPA1 channels in cerebral artery endothelial cells to activate an early adaptive response to reduce tissue ischemic damage through vasodilation.
    1. Ecology

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
    1. Biochemistry and Chemical Biology

    Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

    Rajendra Uprety et al.
    The structure-based design established a new approach to control pathway-selective activation of opioid receptors, resulting in new dual MOR/KOR G-protein biased agonist analgesics with attenuated liabilities.
    1. Cancer Biology
    2. Cell Biology

    A positive feedback loop between Myc and aerobic glycolysis sustains tumor growth in a Drosophila tumor model

    Kenneth Kin Lam Wong et al.
    Specific molecular links that orchestrate growth signals and metabolic reprogramming to achieve tumorigenesis are identified as potential metabolic vulnerabilities in cancer treatment.
    1. Cancer Biology
    2. Cell Biology

    Aurora kinase A localises to mitochondria to control organelle dynamics and energy production

    Giulia Bertolin et al.
    AurkA is imported into mitochondria at interphase, and it induces organelle elongation and enhances ATP production when over-expressed.
    1. Cell Biology
    2. Plant Biology

    Fluorescent sensors reporting the activity of ammonium transceptors in live cells

    Roberto De Michele et al.
    A modified form of Green Fluorescent Protein integrated into an ammonium transporter provides a sensor that can be used to monitor transport activity in vivo.

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