676 results found
    1. Neuroscience

    Activity patterns of serotonin neurons underlying cognitive flexibility

    Sara Matias, Eran Lottem ... Zachary F Mainen
    Recordings from serotonin-producing neurons in the brain reveal that these neurons are highly activated by sudden changes in previously familiar environments, potentially explaining why serotonin is important for learning to adapt to such changes.
    1. Ecology
    2. Evolutionary Biology

    Risk-sensitive learning is a winning strategy for leading an urban invasion

    Alexis J Breen, Dominik Deffner
    Animals can thrive alongside humans by being expert judges of risk.
    1. Neuroscience

    Canonical goal-selective representations are absent from prefrontal cortex in a spatial working memory task requiring behavioral flexibility

    Claudia Böhm, Albert K Lee
    Representation of goals in the forms previously reported in the PFC is not required for performance of a novel spatial working memory task where goal information must be used flexibly.
    1. Neuroscience

    Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibility

    Katherine R Cording, Emilie M Tu ... Helen S Bateup
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Rapid, automated, and experimenter-free touchscreen testing reveals reciprocal interactions between cognitive flexibility and activity-based anorexia in female rats

    Kaixin Huang, Laura K Milton ... Claire J Foldi
    An automated touchscreen cognitive testing system for rats reduces the length of training required to learn tasks, making it possible to assess cognitive profiles in adolescent animals to more appropriately capture cognitive deficits in adolescent pathologies, such as anorexia nervosa.
    1. Neuroscience

    Serial, parallel and hierarchical decision making in primates

    Ariel Zylberberg, Jeannette AM Lorteije ... Pieter Roelfsema
    A comparison between hierarchical and flat models of decision-making refutes flat models because they lack flexibility and are not supported by behavioral and neural data.
    1. Neuroscience

    Behavioral training promotes multiple adaptive processes following acute hearing loss

    Peter Keating, Onayomi Rosenior-Patten ... Andrew J King
    Training enables adult humans to rapidly adapt their sound localization abilities to unilateral hearing loss by combining different strategies that rely on partially distinct neurophysiological substrates.
    1. Neuroscience

    Atypical cognitive training-induced learning and brain plasticity and their relation to insistence on sameness in children with autism

    Jin Liu, Hyesang Chang ... Vinod Menon
    Learning in children with autism spectrum disorder (ASD) was achieved by fundamentally different cognitive and neural mechanisms from typically developing children, and insistence on sameness, a core symptom of ASD, contributed to such atypical mechanisms of learning in affected children.
    1. Neuroscience

    Circuits that encode and guide alcohol-associated preference

    Kristin M Scaplen, Mustafa Talay ... Karla R Kaun
    Alcohol modifies dopaminergic microcircuits required for acquisition and expression of sensory memories in Drosophila resulting in a shift in behavioral response from malleable to inflexible.
    1. Developmental Biology
    2. Neuroscience

    Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods

    Eduardo Loureiro-Campos, António Mateus-Pinheiro ... Luísa Pinto
    Constitutive deficiency of AP2γ transcription factor impairs hippocampal glutamatergic neurogenesis and induces alterations on limbic-cortical connectivity that contribute to anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods.

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