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    1. Neuroscience

    Mediodorsal thalamus is required for discrete phases of goal-directed behavior in macaques

    Evan Wicker, Janita Turchi ... Patrick A Forcelli
    Transient suppression of activity in the macaque mediodorsal thalamus impairs adjustment of secondary reinforcer values and disrupts appropriate action selection in a reinforcer devaluation task; this profile is distinct from that of amygdala or subregions of orbitofrontal cortex.
    1. Developmental Biology
    2. Neuroscience

    The NKCC1 antagonist bumetanide mitigates interneuronopathy associated with ethanol exposure in utero

    Alexander GJ Skorput, Stephanie M Lee ... Hermes H Yeh
    Prenatal ethanol exposure results in aberrant tangential migration by altering NKCC1-mediated chloride homeostasis that can be mitigated by bumetanide.
    1. Neuroscience

    Control of entropy in neural models of environmental state

    Timothy H Muller, Rogier B Mars ... Jill X O'Reilly
    Evidence for neuromodulatory control of flexibility in human neural models.
    1. Evolutionary Biology
    2. Neuroscience

    A small, computationally flexible network produces the phenotypic diversity of song recognition in crickets

    Jan Clemens, Stefan Schöneich ... Berthold Hedwig
    A computational model of the neuronal network that recognizes mating signals reveals network properties that support and constrain behavioral diversity in a species group.
    1. Developmental Biology
    2. Neuroscience

    Linking mPFC circuit maturation to the developmental regulation of emotional memory and cognitive flexibility

    Cassandra B Klune, Benita Jin, Laura A DeNardo
    An analysis of recent literature advances novel hypotheses and suggests new experimental approaches in order to build an integrated understanding of prefrontal neural architecture and behavioral repertoires during development.
    1. Neuroscience

    A resource-rational theory of set size effects in human visual working memory

    Ronald van den Berg, Wei Ji Ma
    Set size effects in visual working memory are explained as a resource-rational trade-off between an error-based behavioral cost and a neural encoding cost.
    1. Neuroscience

    CXCL12-induced rescue of cortical dendritic spines and cognitive flexibility

    Lindsay K Festa, Elena Irollo ... Olimpia Meucci
    Unveiling a novel role of the chemokine CXCL12 in the mature brain that opens up new lines of investigation for the development of therapeutics against cognitive impairment.
    1. Neuroscience

    Serotonergic amplification of odor-evoked neural responses maps onto flexible behavioral outcomes

    Yelyzaveta Bessonova, Baranidharan Raman
    Electrophysiological and behavioral analyses of odor-evoked responses in the locust olfactory system reveal how serotonin uniformly modifies spontaneous and odor-evoked neural activity and yet drive odor-specific changes in behavioral outcomes.
    1. Neuroscience

    Real-time experimental control using network-based parallel processing

    Byounghoon Kim, Shobha Channabasappa Kenchappa ... Ari Rosenberg
    The Real-Time Experimental Control with Graphical User Interface (REC-GUI) framework can facilitate cutting-edge neuroscience research by providing precise experimental control using high-level programming environments familiar to many experimentalists.
    1. Computational and Systems Biology
    2. Neuroscience

    A cholinergic feedback circuit to regulate striatal population uncertainty and optimize reinforcement learning

    Nicholas T Franklin, Michael J Frank
    Computational modeling suggests that feedback between striatal cholinergic neurons and spiny neurons dynamically adjusts learning rates to optimize behavior in a variable world.