Browse the search results

Page 2 of 28
    1. Immunology and Inflammation
    2. Neuroscience

    Drainage of inflammatory macromolecules from the brain to periphery targets the liver for macrophage infiltration

    Linlin Yang et al.
    Circulation of molecules from the brain can serve as a rapid mode of communication from the brain to the liver.
    1. Cell Biology
    2. Immunology and Inflammation

    Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex

    Daniel Blumenthal et al.
    The dendritic cell actin cytoskeleton provides a platform for T cell mechanosensing, delivering novel biophysical cues that serve as costimulatory signals for T cell activation.
    1. Immunology and Inflammation

    Notch and TLR signaling coordinate monocyte cell fate and inflammation

    Jaba Gamrekelashvili et al.
    Notch signaling alters TLR-induced inflammation by skewing monocyte cell fate toward patrolling monocyte differentiation at the expense of macrophage cell fate.
    1. Neuroscience

    Microglial calcium signaling is attuned to neuronal activity in awake mice

    Anthony D Umpierre et al.
    Microglial processes engage calcium signaling in response to hyper- or hypo-active shifts in neuronal activity.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens

    George Ueda et al.
    De novo protein nanoparticles were designed from scratch to present viral glycoprotein antigens, providing a systematic way to study the influence of antigen presentation geometry on immune response.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Chronic ethanol consumption compromises neutrophil function in acute pulmonary Aspergillus fumigatus infection

    Nathalia Luisa Sousa de Oliveira Malacco et al.
    Cell biology analysis demonstrated for the first time the effect of chronic ethanol consumption in neutrophil impaired migration by CXCR2 downregulation and neutrophil function during acute Aspergillus fumigatus infection.
    1. Neuroscience

    Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain

    David Cabañero et al.
    Operant drug self-administration in a mouse model of neuropathic pain reveals pain-relieving effects of a cannabinoid CB2 receptor agonist that are mediated through CB2 receptors of neurons and lymphocytes.
    1. Medicine

    Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

    Ying Ann Chiao et al.
    Mitochondrial-targeted SS-31 peptide ameliorates mitochondrial dysfunction and rescues pre-existing cardiac dysfunction in old mice, supporting the translational potential of mitochondrial protective interventions to treat age-related diseases.
    1. Immunology and Inflammation

    Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse

    Praneeth Chitirala et al.
    A new knock-in mouse endogenously labels cytotoxic granules and can be used with all modern super-resolution imaging techniques to study T cell function in vitro and in vivo.
    1. Immunology and Inflammation
    2. Physics of Living Systems

    Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers

    Marco Molari et al.
    Detailed and inferred model reproduces B-cell affinity distributions measured in mice immunized according to various protocols and explains non-monotonous effects of antigen dosage on maturation.