4,598 results found
    1. Neuroscience

    Visualization of currents in neural models with similar behavior and different conductance densities

    Leandro M Alonso, Eve Marder
    Visualization methods display the dynamics of the currents in conductance-based model neurons, and show how their contribution changes in response to perturbation.
    1. Neuroscience

    Nociceptive interneurons control modular motor pathways to promote escape behavior in Drosophila

    Anita Burgos et al.
    A class of interneuron is identified that promotes escape behavior downstream of nociceptor inputs via connections to nociceptive integrator and premotor networks.
    1. Neuroscience

    Modular organization of cerebellar climbing fiber inputs during goal-directed behavior

    Shinichiro Tsutsumi et al.
    Motor and non-motor functions are represented in spatially segregated and temporally organized climbing fiber signals to distinct cerebellar zones during goal-directed behavior.
    1. Neuroscience

    Nonlinear circuits for naturalistic visual motion estimation

    James E Fitzgerald, Damon A Clark
    New computational models provide insights into how the insect brain estimates the speed and direction of movement.
    1. Neuroscience

    Reverse-correlation analysis of navigation dynamics in Drosophila larva using optogenetics

    Luis Hernandez-Nunez et al.
    Optogenetic stimulation of odor- and taste-sensing neurons of the fruit fly larva combined with reverse-correlation analysis has been used to build mathematical models that predict navigational behavior.
    1. Neuroscience

    Cerebellar Purkinje cell activity modulates aggressive behavior

    Skyler L Jackman et al.
    Optogenetic control of Purkinje cells in the cerebellar vermis enables bidirectional control of aggression.
    1. Neuroscience

    Whole brain delivery of an instability-prone Mecp2 transgene improves behavioral and molecular pathological defects in mouse models of Rett syndrome

    Mirko Luoni et al.
    Global brain transduction of the instability-prone Mecp2 transgene by systemic AAV-PHP.eB administration is safe and effective in protecting male and female Mecp2 mutant mice from the Rett syndrome disease phenotype.
    1. Cancer Biology
    2. Computational and Systems Biology

    Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes

    Rolando Ruiz-Vega et al.
    Spontaneous growth arrest of transformed melanocytes (resulting in benign “moles”) does not result from cell-autonomous oncogene-induced senescence, but can be explained by collective mechanisms used in normal tissue size control.
    1. Neuroscience

    MAPLE (modular automated platform for large-scale experiments), a robot for integrated organism-handling and phenotyping

    Tom Alisch et al.
    A new versatile, autonomous, robotic experimental platform (MAPLE) can increase the throughput of biological experiments by automating the growth and phenotyping of a variety of model organisms.
    1. Neuroscience
    2. Physics of Living Systems

    Variability in locomotor dynamics reveals the critical role of feedback in task control

    Ismail Uyanik et al.
    Animals rely on sensory feedback rather than the precise tuning in the nervous system to achieve robust behavioral performances.

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