243 results found
    1. Structural Biology and Molecular Biophysics

    Structure of mycobacterial CIII2CIV2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203)

    David J Yanofsky et al.
    The structure of the Mycobacterium smegmatis CIII2CIV2 respiratory supercomplex with telacebec (Q203) bound shows how this tuberculosis drug candidate blocks respiration in mycobacteria.
    1. Genetics and Genomics

    Utility of polygenic embryo screening for disease depends on the selection strategy

    Todd Lencz et al.
    Preimplantation screening of embryos using polygenic risk scores may substantially reduce risk for a given complex disease, but this effect depends on several quantifiable factors and raises significant ethical issues.
    1. Epidemiology and Global Health

    Telomere length is associated with growth in children in rural Bangladesh

    Audrie Lin et al.
    In a rural, low-income setting in Bangladesh, early-life telomere length was associated with concurrent growth.
    1. Neuroscience

    Neural excitability and sensory input determine intensity perception with opposing directions in initial cortical responses

    Tilman Stephani et al.
    Larger evoked responses during initial cortical processing may reflect states of lower excitability.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics

    Michael I Barton et al.
    Common variants of the SARS-CoV-2 Spike protein and its ligand, the human ACE2 receptor, increase the binding affinity, suggesting that they could increase viral transmissibility.
    1. Neuroscience

    Coherent theta activity in the medial and orbital frontal cortices encodes reward value

    Linda M Amarante, Mark Laubach
    The more you want it or the better it is, the stronger is medial frontal theta (paraphrased from a retweet of the preprint by Dr James Hyman).
    1. Genetics and Genomics
    2. Neuroscience

    A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons

    Gha-Hyun J Kim et al.
    In vivo dopamine neuron imaging-based neuroprotective small molecule screen in larval zebrafish and mechanistic investigation using conditional CRISPR knockout and cell-type-specific RNA-seq analysis, coupled with cross-species analyses including human clinical data interrogation, uncover potential disease-modifying therapeutics for Parkinson's disease (PD).
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Characterizing human mobility patterns in rural settings of sub-Saharan Africa

    Hannah R Meredith et al.
    Mobile phone data reveal aspects of human mobility patterns in Sub-Saharan Africa missed by standard spatial models however, model estimates can be improved by accounting for trip urbanicity and region.
    1. Physics of Living Systems

    Muscle-specific economy of force generation and efficiency of work production during human running

    Sebastian Bohm et al.
    During human running, the soleus muscle was found to operate as work generator under optimal conditions for work production (high force-length potential and enthalpy efficiency) while the vastus lateralis promoted tendon energy storage and economical force generation (high force-length-velocity potential).
    1. Epidemiology and Global Health

    Cancer risk perception and physician communication behaviors on cervical cancer and colorectal cancer screening

    Diane M Harper et al.
    The physician involving the woman as much as she wants in her health care is significantly associated with up-to-date dual cervical and colorectal cancer screening compared to being up to date in only cervical cancer screening.

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