Mice doubly deficient for Naa10 and Naa12 display embryonic lethality, with both enzymes compensating for each other with amino-terminal acetylation of proteins in mouse development.

AGRP neurons integrate environmental food-related cues with internal metabolic signals to modulate interscapular brown adipose tissue thermogenesis and energy expenditure, at least in part, via mTORC1 signalling.

Plasma lipidomic profiling in pregnancy, infancy and early childhood provides a framework to define the relationship between lipid metabolism and health outcomes in early childhood.

Integrative analysis of multi-tissue transcriptomics data of mice subjected to cold, mild warm or room temperature places the thermal adaptation of individual tissues in a whole-organism perspective.

Fibroblast growth factor 21 blocks hepatic lipid influx and accumulation, prevents Kupffer cell activation, and inhibits the formation of hepatic lipid- and scar-associated macrophages, thereby likely inhibiting fibrogenesis in nonalcoholic steatohepatitis in humanized APOE*3-Leiden.CETP mice.

Sulforaphane through NRF2-dependent and -independent cellular and molecular pathways alleviates leptin resistance to reverse the diet-induced obesity.

NFATc1 is identified as a molecular marker of articular cartilage progenitor cells and a transcriptional repressor of chondrocyte differentiation, providing fundamental insights into the origin and differentiation mechanism of articular chondrocytes.

Mice carrying a near-complete human chromosome 21 are hypermetabolic and have increased thermogenesis due to sarcolipin overexpression in the skeletal muscle, leading to persistent uncoupling of the sarco(endo)plasmic reticulum Ca²⁺ ATPase pump activity and heat generation.