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    1. Developmental Biology

    TAF7L modulates brown adipose tissue formation

    Haiying Zhou, Bo Wan ... Robert Tjian
    TAF7L acts as a molecular switch that regulates the development of mesenchymal stem cells.
    1. Cell Biology

    Dnmt3a is an epigenetic mediator of adipose insulin resistance

    Dongjoo You, Emma Nilsson ... Sona Kang
    Mouse and tissue culture studies reveal that adipose DNA methyltransferase 3a mediates insulin resistance, partially through repressing the expression of FGF21.
    1. Cell Biology

    Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits

    Ziru Li, Emily Bowers ... Ormond A MacDougald
    Bone marrow adipocyte lipolysis is required for maintaining bone mass under conditions of energy deficiency and is necessary for myelopoiesis following caloric restriction and irradiation.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Aggregating in vitro-grown adipocytes to produce macroscale cell-cultured fat tissue with tunable lipid compositions for food applications

    John Se Kit Yuen Jr, Michael K Saad ... David L Kaplan
    A simple way to create larger volumes of fat tissue for food purposes may be to grow individual fat cells and mechanically combine them together (rather than directly growing the full tissue).
    1. Cell Biology

    Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

    Zewei Zhao, Longyun Hu ... Zhonghan Yang
    ADGRA3 signaling promotes adipose thermogenesis via Gs-PKA-CREB, suggesting hesperetin and ADGRA3 overexpression as obesity therapies.
    1. Medicine

    Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity

    Chandramohan Chitraju, Alexander W Fischer ... Robert V Farese Jr
    Inhibiting triglyceride storage in adipose tissue prevents obesity and improves metabolic health.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells

    Jiajia Xu, Yiyun Wang ... Aaron W James
    CD107a expression divides osteogenic from adipogenic perivascular precursor cells within human white adipose tissue.
    1. Biochemistry and Chemical Biology

    Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity

    Tingqing Guo, Patricia Marmol ... Carlos F Ibanez
    The ALK7 receptor functions cell-autonomously and homeostatically in adult adipocytes to regulate catecholamine sensitivity in response to the diet.
    1. Developmental Biology

    A neurogenic signature involving monoamine Oxidase-A controls human thermogenic adipose tissue development

    Javier Solivan-Rivera, Zinger Yang Loureiro ... Silvia Corvera
    A hybrid mouse/human model using mesenchymal progenitor cells reveals dynamics of human adipose tissue development and mechanisms that may enhance human adipose thermogenic capacity.
    1. Cell Biology

    Deconstructing cold-induced brown adipocyte neogenesis in mice

    Rayanne B Burl, Elizabeth Ann Rondini ... James G Granneman
    Single-cell RNA-sequencing, spatial genomics, and histological analyses reveal that cold-induced brown adipose neogenesis is a complex adaptive response to elevated metabolic demand involving dynamic interactions between recruited immune cells and a subpopulation of poised adipocyte progenitors.