C-terminal phosphorylation of the lipid phosphatase PTEN drives a reduction in membrane affinity and leads to a more compact conformation that involves a C2 domain-tail interaction.

A set of genes that are turned on only within time-limited windows—including genes encoding RNA binding molecules, let-7 microRNAs and IMP1—control developmental switches in stem cell properties between fetal development and adulthood.

Phosphorylation of the Wnt receptor LRP6 directly inhibits glycogen synthase kinase-3 by acting as a pseudosubstrate that stabilizes an active conformation of the enzyme, identical to autoinhibition by phosphorylation of its N terminus.

Non-invasive MEG recordings reveal that patterns of spontaneous activity in the resting brain are shorter lived than previously thought.

The rhythmic patterns of activity that underlie breathing are generated and coordinated by distinct populations of neurons within the brainstem.

Genetic rescue experiments reveal that γ-secretase enzymes containing Aph1b subunits control signalling by type III neuregulin 1, with implications for schizophrenia.

Arabidopsis lysozyme LYS1 generates soluble peptidoglycan fragments to mediate pattern-triggered immunity.

The convergent evolution of unusually strict substrate specificity in apicomplexan LDHs arose by classic neofunctionalization of a duplicated MDH gene via few mutations of large effect.

The ALK7 receptor functions cell-autonomously and homeostatically in adult adipocytes to regulate catecholamine sensitivity in response to the diet.

The T-cell receptors of gamma delta (γδ) T cells can recognize and trigger responses to small molecules and are thereby versatile drivers of immunity.