2,650 results found
    1. Immunology and Inflammation

    Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature

    Chao Yang et al.
    T-bet suppresses the expression of immature NK cell-defining genes.
    1. Cell Biology

    Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish

    Sharan Janjuha et al.
    During aging, the pancreatic endocrine islets undergo chronic inflammation, which is associated with a reduced capacity for self-renewal of the insulin-producing beta-cells in zebrafish.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development

    Jennifer Hampton Hill et al.
    A previously undescribed protein produced by certain resident intestinal bacteria induces zebrafish pancreatic beta cell expansion.
    1. Immunology and Inflammation

    c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells

    Caroline Tizian et al.
    c-Maf is a novel key regulator of the type 3-to-1 conversion of CCR6 ILC3s that controls the functional plasticity of ILC3s by acting as a cell-intrinsic gatekeeper of T-bet expression.
    1. Stem Cells and Regenerative Medicine

    Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

    Diego Balboa et al.
    Mutations causing proinsulin misfolding trigger unfolded protein response and lead to impaired proliferation and reduced mTORC1 signalling of developing beta-cells in a patient-derived induced pluripotent stem cell disease model.
    1. Immunology and Inflammation

    IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation

    Esther Zumaquero et al.
    IFNγ increases the responsiveness of human B cells to IL-2, TLR7/8 and IL-21 signals and therefore enhances antibody production in inflammatory settings associated with autoimmune or chronic disease.
    1. Stem Cells and Regenerative Medicine

    Insulin: Folding mutations suppress early beta-cell proliferation

    Honey Modi, James D Johnson
    Exploring how proliferation and maturation of beta-cells can be impaired after birth will shed light on the origins of various forms of diabetes.
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    1. Immunology and Inflammation

    The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa

    Heather D Marshall et al.
    Differentiation of CD4 T cells into CD4 T follicular helper cells during viral infection in mice is promoted by tumor growth factor beta.
    1. Genetics and Genomics
    2. Neuroscience

    A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture

    Mark F Sabbagh, Jeremy Nathans
    In vitro culture of brain endothelial cells leads to a rapid loss of the blood-brain barrier transcriptional and accessible chromatin landscapes that is resistant to the effects of beta-catenin stabilization.
    1. Epidemiology and Global Health
    2. Medicine

    Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial

    Manoj M Lalu et al.
    A rigorous and transparent evaluation of mesenchymal stem cell therapy for sepsis suggests it may be efficacious, although the strength of these findings is tempered by threats to validity in the studies that were included.

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