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    1. Neuroscience

    Alpha/beta power decreases track the fidelity of stimulus-specific information

    Benjamin James Griffiths, Stephen D Mayhew ... Simon Hanslmayr
    Neural representations of stimulus-specific information increase in fidelity as the power of alpha/beta activity decreases, suggesting that alpha/beta power decreases reflect a domain-general mechanism that supports information representation.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Homology-guided identification of a conserved motif linking the antiviral functions of IFITM3 to its oligomeric state

    Kazi Rahman, Charles A Coomer ... Alex A Compton
    A disease-associated polymorphism in a related protein that regulates neurotransmitter release reveals that antiviral protein IFITM3 forms oligomers to rigidify membranes and inhibit virus fusion with cells.
    1. Structural Biology and Molecular Biophysics

    The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model

    Achinta Sannigrahi, Sourav Chowdhury ... Krishnananda Chattopadhyay
    How do the metal cofactors present in the protein SOD1 collaborate with the interacting membrane to define the role of this protein in the disease ALS?
    1. Cell Biology
    2. Developmental Biology

    Aurora A and cortical flows promote polarization and cytokinesis by inducing asymmetric ECT-2 accumulation

    Katrina M Longhini, Michael Glotzer
    Centrosomal Aurora A (AIR-1), together with cortical actomyosin flows, induces polarization of ECT-2, the activator of RHO-1, during polarization and cytokinesis, in order to promote furrow formation.
    1. Neuroscience

    Spatially displaced excitation contributes to the encoding of interrupted motion by a retinal direction-selective circuit

    Jennifer Ding, Albert Chen ... Wei Wei
    The direction-selective circuit in the retina adjusts the contributions of excitatory and inhibitory mechanisms under different stimulus conditions to generate context-dependent neural representations of visual features.
    1. Neuroscience

    Spatial sampling in human visual cortex is modulated by both spatial and feature-based attention

    Daniel Marten van Es, Jan Theeuwes, Tomas Knapen
    The sampling of visual space is not only warped by attention towards locations but also depends on attended features.
    1. Neuroscience

    Intracranial human recordings reveal association between neural activity and perceived intensity for the pain of others in the insula

    Efe Soyman, Rune Bruls ... Valeria Gazzola
    Intracranial recordings indicate that the insula encodes, in a partially intermixed layout, both static and dynamic cues from different body parts that reflect the intensity of pain experienced by others.
    1. Microbiology and Infectious Disease

    Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid

    Ke Peng, Walter Muranyi ... Hans-Georg Kräusslich
    A robust method to quantitatively visualize HIV-1 replication complexes in infected cells shows that these complexes remain associated with the viral capsid beyond nuclear import in primary macrophages.
    1. Developmental Biology
    2. Neuroscience

    Commissureless acts as a substrate adapter in a conserved Nedd4 E3 ubiquitin ligase pathway to promote axon growth across the midline

    Kelly G Sullivan, Greg J Bashaw
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments

    Scott D Hansen, R Dyche Mullins
    Lamellipodin, an important regulator of cytoskeletal and assembly cell migration, enhances the activity of Ena/VASP family actin polymerases by clustering them on leading-edge membranes and tethering them to actin filaments.