Linking deep mutational scanning with engineered transcriptional reporters in human cell lines establishes a generalizable method for exploring pharmacogenomics, structure, and function across broad classes of drug receptors.

Experiments in genetically modified zebrafish that are unable to produce norepinephrine show that this neurotransmitter promotes wakefulness by mediating the effects of the neuropeptide hypocretin.

FRET biosensor-based measurement of cAMP signaling and single-channel recording reveal that β-blockers trigger local activation of adrenergic receptors and calcium channels in primary neurons.

Structure-function characterization of the EMC's cytoplasmic, transmembrane, and lumenal domains reveal features critical for terminal helix insertion and a specialized role for the lumenal domain in polytopic membrane protein biogenesis.

The activin receptor ALK7 regulates the adaptation of brown adipose tissue to nutrient availability by preventing over-activation of signaling pathways induced by fasting, allowing appropriate response to cold exposure.

Heterotrimeric G proteins are less abundant on endosomes and organelles than on the plasma membrane.

The activation of beige adipocyte thermogenesis by cold temperatures and β3-adrenergic receptor agonists induce beige adipocyte formation, function and perdurance.

Identification of the R(+)-propranolol enantiomer as an inhibitor of the SOX18 transcription factor activity breaks open potential of drug repurposing in vascular diseases.

Using long-term in vivo imaging with miniature two-photon microscopy, microglia surveillance is sleep state-dependent and stress-induced in freely behaving mice, regulated by the locus coeruleus-norepinephrine system and β₂-adrenergic receptors signaling.

Amyloid beta, the major component of plaques in Alzheimer's disease, acutely and reversibly signals to modulate sleep as a function of oligomeric length, independently of neuronal loss.