A shift in fitness optimum of a polygenic trait rapidly introduces small frequency differences between alleles with effects aligned with and opposing the shift, which gradually translate into small differences in fixation probability.

Bacterial CRISPR immunity tracks phage mutations, creating immune diversity in bacterial populations that parallels phage genetic diversity and patterns of phage evolution that are determined by the type and degree of immune cross-reactivity in the CRISPR system.

To make reliable but metabolically efficient perceptual inferences in a changing world, neural systems should dynamically adapt based on surprise and uncertainty about the sensory environment.

Gradient-descent synaptic plasticity applied to neuroscience categorization tasks captures the behaviour of common neural activity measures (category and context selectivity, correlation, asymmetry) reported in experiments, and makes novel experimental predictions.

CapZ controls actin filament density around immature early endosomes via its C-terminal domain to facilitate the homotypic fusion of the endocytic vesicles, and it functions as a scaffold protein via its N-terminal domain to recruit RAB5 effectors to early endosomes.

A chemical probe was characterized for potency, selectivity, and ability to alter CARM1-dependent epigenetic plasticity against cancer cell invasion.

A principled statistical segmentation of fruit fly walking leads to a compact model of immediate actions that can reproduce the unique behavioral sequences of individual flies.