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    1. Neuroscience

    Suggestion of creatine as a new neurotransmitter by approaches ranging from chemical analysis and biochemistry to electrophysiology

    Xiling Bian, Jiemin Zhu ... Yi Rao
    While neurotransmitters were discovered decades ago, evidence suggests that more transmitters are to be discovered using the presented approaches.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Rapid, Reference-Free human genotype imputation with denoising autoencoders

    Raquel Dias, Doug Evans ... Ali Torkamani
    A new autoencoder-based genotype imputation method shows superior accuracy across human genomes of diverse ancestry and across the allele-frequency spectrum, while delivering significantly faster inference run times relative to standard imputation tools.
    1. Cancer Biology
    2. Genetics and Genomics

    High-grade serous ovarian carcinoma organoids as models of chromosomal instability

    Maria Vias, Lena Morrill Gavarró ... James D Brenton
    Fifteen continuous high-grade serous ovarian carcinoma patient-derived organoids are characterized by transcriptomic, genomic, and drug sensitivity assays to reveal that they comprise communities of clonal populations and represent models of different causes of chromosomal instability and degrees of genome complexity.
    1. Computational and Systems Biology

    Emergence of power law distributions in protein-protein interaction networks through study bias

    David B Blumenthal, Marta Lucchetta ... Martin H Schaefer
    Biased research interest in proteins and aggregation of interactions from multiple studies can explain why node degree distributions in protein-protein interaction networks follow a power law.
    1. Neuroscience

    A bidirectional corticoamygdala circuit for the encoding and retrieval of detailed reward memories

    Ana C Sias, Ashleigh K Morse ... Kate M Wassum
    The bidirectional orbitofrontal cortex-basolateral amygdala circuit helps us to learn the details of predicted rewarding events and then to use that information to make good reward pursuit decisions.
    1. Neuroscience

    Numerical magnitude, rather than individual bias, explains spatial numerical association in newborn chicks

    Rosa Rugani, Giorgio Vallortigara ... Lucia Regolin
    Spatial numerical association in three-day-old domestic chicks linearly decreases as numerical magnitude increases (2>5>8), supporting the hypothesis that numerical magnitude guides the spatial numerical association.
    1. Cancer Biology

    The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution

    Gui-Zhen Wang, Xin Cheng ... Guang-Biao Zhou
    The chemokine CXCL13 is critical to the development of air pollution- and tobacco smoke-induced lung cancers.
    1. Epidemiology and Global Health
    2. Neuroscience

    Attention-deficit hyperactivity disorder symptoms and brain morphology: Examining confounding bias

    Lorenza Dall'Aglio, Hannah H Kim ... Henning Tiemeier
    Approximately half of the associations identified between attention-deficit/hyperactivity disorder and brain morphology in two large independent studies of adolescents are likely due to confounding bias by socioeconomic and parental behavioral factors.
    1. Physics of Living Systems

    Distinct contributions of the thin and thick filaments to length-dependent activation in heart muscle

    Xuemeng Zhang, Thomas Kampourakis ... Yin-Biao Sun
    The Frank–Starling law of the heart and its underlying mechanism of length-dependent activation involve distinctive structural changes in both the thin and thick filaments of cardiac muscle cells.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Hydrop enables droplet-based single-cell ATAC-seq and single-cell RNA-seq using dissolvable hydrogel beads

    Florian V De Rop, Joy N Ismail ... Stein Aerts
    New open-source method contains all the tools for extracting open chromatin or RNA from thousands of single cells in parallel for <5% of the cost of state-of-the-art commercial alternatives, paving the way for whole-tissue atlasing and new protocol development.