46 results found
    1. Structural Biology and Molecular Biophysics

    Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex

    Thomas E Sladewski et al.
    mRNA cargo orchestrates the activation of an in vitro reconstituted dynein-dynactin-Bicaudal D-Egalitarian complex for robust processive motion on microtubules.
    1. Neuroscience

    Microsecond interaural time difference discrimination restored by cochlear implants after neonatal deafness

    Nicole Rosskothen-Kuhl et al.
    Early deaf human CI users are often insensitive to sub-millisecond interaural time differences (ITDs); however, with synchronized CIs, early deafened rats learned to lateralize small ITDs near 50 µs.
    1. Neuroscience

    Decoding neural responses to temporal cues for sound localization

    Dan FM Goodman et al.
    Computer simulations of interaural time difference decoders show that heterogeneous tuning of binaural neurons leads to accurate sound localization in natural environments.
    1. Cell Biology

    RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs

    Mark A McClintock et al.
    Reconstitution of dynein-based mRNA transport with purified components reveals a pivotal role of an RNA localisation signal in controlling the assembly and activity of the translocation machinery.
    1. Neuroscience

    Natural ITD statistics predict human auditory spatial perception

    Rodrigo Pavão et al.
    Human brain has incorporated natural statistics of spatial cues to the neural code supporting perception of sound location.
    1. Neuroscience

    Principal cells of the brainstem’s interaural sound level detector are temporal differentiators rather than integrators

    Tom P Franken et al.
    Principal neurons of the brainstem nucleus comparing sound level at the two ears do not have the slow response properties previously attributed to them, but are instead specialized for fast weighing of excitation and inhibition.
    1. Neuroscience

    Behavioral training promotes multiple adaptive processes following acute hearing loss

    Peter Keating et al.
    Training enables adult humans to rapidly adapt their sound localization abilities to unilateral hearing loss by combining different strategies that rely on partially distinct neurophysiological substrates.
    1. Neuroscience

    Glycinergic axonal inhibition subserves acute spatial sensitivity to sudden increases in sound intensity

    Tom P Franken et al.
    The location of impact sounds, common stimuli whose detection is crucial for survival, is encoded by a precise interaction between excitation and inhibition rather than coincidence detection of excitatory events.
    1. Neuroscience

    Individual differences in selective attention predict speech identification at a cocktail party

    Daniel Oberfeld, Felicitas Klöckner-Nowotny
    Cocktail-party listening performance in normal-hearing listeners is associated with the ability to focus attention on a target stimulus in the presence of distractors.
    1. Computational and Systems Biology
    2. Neuroscience

    Neural tuning matches frequency-dependent time differences between the ears

    Victor Benichoux et al.
    Complex properties of space-sensitive auditory neurons in cats mirror the complexity of acoustical environments.

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