Combining in silico and experimental approaches to identify and understand the residue changes in the H-NS protein that allowed bacteria to adapt environment-sensing to different habitats.

The detection of chemical synapses in 3-dimensional electron microscopy data has been automated such that synapses in large-scale connectivity maps of the cerebral cortex, connectomes, can be charted without the need for human interaction.

The MIR domain of protein-O-mannosyltransferases participates in glycosylation by binding mannosylated peptides and regulates enzyme processivity.

New biophysical methods and analyses visualize in real-time a chain of coordinated single-molecular events on a living cell, enabling the inner workings of a mechanoreceptor important to biology to be elucidated.

Phosphatidylglycerol binding at multiple sites stabilizes the open state relative to the desensitized state of a pentameric ligand-gated ion channel.

Expanded repeat RNAs associated with human neurodegenerative diseases can become incorporated into transported granules in neurons, perturbing their function to cause neuritic branching defects.

Drosophila has almost all transcription factor binding specificities available to humans; and human transcription factors with divergent specificities operate in cell types that are not found in fruit flies.

RNA binding is a key input of an active chromatin complex and maintenance of stem cell fate.

lncDACH1 is a novel regulator of sodium channel, which suppresses the membrane trafficking of Nav1.5 by disturbing the function of dystrophin.

Pharmacological activation of farnesoid X (FXR) receptor by hammerhead-type agonists induces a novel enhancer RNA, termed Fincor, contributing to the amelioration of nonalcoholic steatohepatitis in mice.