2,540 results found
    1. Chromosomes and Gene Expression

    Local chromosome context is a major determinant of crossover pathway biochemistry during budding yeast meiosis

    Darpan Medhi et al.
    Different homologous recombination pathways are dominant in different regions of meiotic chromosomes, indicating that chromosome structure influences recombination biochemistry.
    1. Biochemistry and Chemical Biology

    Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action

    Jonathan B Steinman et al.
    Analyses of the chemical structure of ciliobrevins led to dynein inhibitors with improved properties and higher potency.
    1. Chromosomes and Gene Expression

    Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays

    Winnie Tan et al.
    Biochemical reconstitution experiments uncover the ubiquitin-mediated function of a DNA repair protein, key to the understanding of Fanconi Anemia, a cancer-associated bone marrow failure syndrome.
    1. Neuroscience

    Misaligned feeding impairs memories

    Dawn H Loh et al.
    The time at which mice consume food can dramatically affect hippocampal-dependent biochemistry, physiology, and learned behavior.
  1. Less writing, more industry: an interview with Dennis Breitsprecher

    After completing a PhD in biochemistry, Dennis Breitsprecher was sure that he wanted to pursue an academic career. However, he grew bored of constantly writing papers and grant applications as a postdoc, and is now Head of Biochemistry R&D at NanoTemper in Munich.
    1. Biochemistry and Chemical Biology

    Webinar Report: Unpuzzling proteins

    Ivan Dikic, eLife Senior Editor, and his guests discussed the most exciting discoveries and challenges at the forefront of protein biochemistry.
  2. Controlling traffic: an interview with Ramanath Hegde

    Ramanath Hegde is a Postdoctoral Fellow at the Institute of Protein Biochemistry in Naples, Italy, where he investigates ways of preventing cells from destroying mutant proteins. He maintains his original interest in engineering through a variety of hobbies, including carpentry.
    1. Structural Biology and Molecular Biophysics

    Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch

    Jonathan M Philpott et al.
    A conformational switch in the Casein Kinase 1 activation loop controls substrate preference to regulate the abundance of the clock protein PERIOD2 and circadian timekeeping.

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