The identification of ACNQ as an extracellular electron shuttle solves a longstanding problem in bacterial physiology and provides new tool for bioenergy development.

Photosystem II, the pigment-protein complex responsible for water oxidation in photosynthesis, was found to exist in two different core conformations with altered antennae connectivity.

Structural analysis reveals large-scale conformational changes in the active site metallocluster of a CO2-fixing enzyme.

A randomized CRISPR-based gene silencing approach overcomes functional redundancy and discovers virulence-critical gene combinations in the pathogen Legionella pneumophila.

The molecular mechanisms of FCPI assembly and selective binding are revealed through comparison of PSI-FCPI structures in two diatom species.

Phenotypic heterogeneity at the single-cell level of cellulosomal machinery biosynthesis suggests a division-of-labor strategy as revealed by the nanoscale mechanistic and ecological investigation of in situ structure and distribution of cellulosomes on bacteria while interacting with the cellulosic substrate.

Recent functional changes in ancient duplicate genes led to the evolution of divergent regulatory and metabolic strategies by the GALactose gene networks of two yeast species.

Stimulation of the rate-limiting enzyme in the NAD salvage pathway protected against neurotoxicity and subsequent peripheral neuropathy associated with the widely utilized anticancer drug, paclitaxel.

Sequence-variant analogs of mitochondria-targeted tetrapeptides have distinct patterns of membrane-bound conformations, effects on membrane properties, and abilities to protect mitochondria subject to stress, illuminating how side chain variation can be leveraged in the development of more effective therapeutic compounds.