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    1. Neuroscience

    Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact

    Thomas A Ray, Suva Roy ... Jeremy N Kay
    Selective synapse formation in a retinal motion-sensitive circuit is orchestrated by starburst amacrine cells, which use homotypic interactions to initiate formation of a dendritic scaffold that recruits projections from circuit partners.
    1. Computational and Systems Biology
    2. Neuroscience

    Principles for coding associative memories in a compact neural network

    Christian Pritz, Eyal Itskovits ... Alon Zaslaver
    A compact neural network can form various associative memories that are encoded in a distributed manner, where each neuron stores different components of the memory.
    1. Computational and Systems Biology
    2. Neuroscience

    Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans

    Rany Abend, Diana Burk ... Bruno B Averbeck
    Applying computational modeling to quantify threat learning processes uncovers how variations in these conserved learning processes relate to anxiety severity and the neuroanatomical substrates moderating these associations.
    1. Neuroscience

    Minian, an open-source miniscope analysis pipeline

    Zhe Dong, William Mau ... Denise J Cai
    Minian is an open-source analysis pipeline for calcium imaging data that enhances usability with low memory demands and transparency with user-friendly interactive visualizations.
    1. Chromosomes and Gene Expression

    Prevalent and dynamic binding of the cell cycle checkpoint kinase Rad53 to gene promoters

    Yi-Jun Sheu, Risa Karakida Kawaguchi ... Bruce Stillman
    The localization of Rad53 cell cycle checkpoint kinase to many gene promoters and the dynamic changes in response to replication stress suggests that the kinase may coordinate genome stability and gene expression.
    1. Neuroscience

    An excitatory lateral hypothalamic circuit orchestrating pain behaviors in mice

    Justin N Siemian, Miguel A Arenivar ... Yeka Aponte
    A small population of lateral hypothalamic neurons detects pain and can be activated to suppress pain-related behavioral adaptations and the unpleasantness associated with pain in mice.
    1. Neuroscience

    A statistical framework to assess cross-frequency coupling while accounting for confounding analysis effects

    Jessica K Nadalin, Louis-Emmanuel Martinet ... Mark A Kramer
    A new measure for cross-frequency coupling assesses phase-amplitude coupling and amplitude-amplitude coupling, and accounts for confounding factors such as low-frequency amplitude fluctuations, using a flexible statistical modeling approach.
    1. Ecology
    2. Evolutionary Biology

    Effects of domestication on the gut microbiota parallel those of human industrialization

    Aspen T Reese, Katia S Chadaideh ... Rachel N Carmody
    Gut microbial signatures of domestication parallel those of industrialization, implicating shared ecological drivers.
    1. Neuroscience

    Transitioning between preparatory and precisely sequenced neuronal activity in production of a skilled behavior

    Vamsi K Daliparthi, Ryosuke O Tachibana ... Todd F Roberts
    Precisely sequenced patterns of neuronal activity associated with the production of a skilled behavior begin and end as part of orchestrated activity across functionally diverse populations of cortical premotor neurons.
    1. Neuroscience

    Modified viral-genetic mapping reveals local and global connectivity relationships of ventral tegmental area dopamine cells

    Kevin Beier
    A modified viral strategy reveals that ventral tegmental area dopamine cells receive substantial inputs from local sources, including distributed GABAergic and serotonergic inputs from the midbrain as well as extensive inputs from other midbrain dopamine cells.