Comprehensive mass spectrometry analysis of human plasma proteome reveals tissue leakage proteins, describes variability between individual plasma proteomes and demonstrates protein transfer across the placenta during pregnancy.

Proteomic profiling of extracellular vesicle proteins from patients with benign and malignant pancreatic diseases offers a valuable resource for identifying biomarkers for pancreatic cancer detection.

Distance-based TCR analysis enables grouping of biochemically similar clonotypes into meta-clonotypes that have increased publicity, and therefore statistical power, for population-level detection of antigen-specific T cells in infection and vaccination.

Quantification of uncertainty in drug dose-responses provides a more robust metric for differentiating drugs and identifying biomarkers of response.

Multiscale Graph Correlation, an interpretable hypothesis test with strong theoretical guarantees for discerning relationships in complex data, requires about half the sample size as other methods, whilst maintaining computational tractability.

Metabolomic analyses have developed and validated serum androstenedione as a reliable and effective diagnostic and predictive biomarker for primary angle closure glaucoma in clinical routines.

A computational method based on optimal transport enables state-of-the-art alignment between untargeted metabolomic studies and is evaluated on cord blood and cancer datasets.

Integrated molecular analysis demonstrated that colorectal cancer can be classified into four molecular subtypes (proliferative, immunomodulatory, immunosuppressed, and immune-excluded subtypes), providing valuable insight into the intricate relationship between tumor microenvironment heterogeneity and various clinical phenotypes.

Comparative analysis establishes genetic links among angioimmunoblastic T-cell lymphoma (AITL), clonal hematopoiesis, and concomitant hematologic malignancies, and provides insights into the cell of origin, etiology, and biomarker discovery for AITL.

Human plasma contains protein-protected mRNA fragments, myriad repeat RNAs, and novel intron RNAs, including a family of structured full-length excised introns, some corresponding to mirtron pre-miRNAs and agotrons.