10 results found
    1. Structural Biology and Molecular Biophysics

    Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals

    Lining Ju et al.
    New biophysical methods and analyses visualize in real-time a chain of coordinated single-molecular events on a living cell, enabling the inner workings of a mechanoreceptor important to biology to be elucidated.
    1. Biochemistry and Chemical Biology

    Mechano-redox control of integrin de-adhesion

    Freda Passam et al.
    Ligand binding, force and chemistry combine to control the function of a cell surface receptor.
    1. Developmental Biology

    Axon tension regulates fasciculation/defasciculation through the control of axon shaft zippering

    Daniel Šmít et al.
    Competition between adhesive and tensile forces regulates axon fasciculation, thus introducing a new role of mechanical tension in the development of neural networks.
  1. Harnessing forces: an interview with Lining (Arnold) Ju

    On reading that the 21st century would be known as the century of biology, mechanical engineering graduate Lining (Arnold) Ju decided to pursue a PhD in biomedical engineering. He is currently a postdoc at the Heart Research Institute and a lecturer at the University of Sydney in Australia, where he studies how platelets sense mechanical forces and how problems in this process can lead to various blood diseases.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Mechanism of allosteric regulation of β2-adrenergic receptor by cholesterol

    Moutusi Manna et al.
    Atomistic simulations reveal how lipids can allosterically modulate membrane receptors.
    1. Immunology and Inflammation

    Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding

    Zhixun Shen et al.
    Conformational changes occur within extracellular domain of BCR upon antigen engagement, and these conformational changes are related with the strength of BCR activation and are distinct in IgM- and IgG-BCR.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components

    Julia P Steringer et al.
    The first reconstitution of an unconventional secretory mechanism uncovered the molecular mechanism by which Fibroblast Growth Factor 2 is secreted from mammalian cells.
    1. Biochemistry and Chemical Biology
    2. Human Biology and Medicine

    The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation

    Tobias Willer et al.
    Post-phosphoryl modification of α-dystroglycan requires the glucuronyltransferase B4GAT1; this enzyme synthesizes the acceptor glycan that serves as a primer for the glycosyltransferase LARGE to synthesize the laminin-binding glycan.
    1. Biochemistry and Chemical Biology

    Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets

    Simon Erlendsson et al.
    Investigations of binding of the scaffold protein PICK1 to transmembrane proteins in their native membrane environment demonstrate potent but slow dynamics and reveal distinct binding modes supporting different biological functions.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The role of scaffold reshaping and disassembly in dynamin driven membrane fission

    Martina Pannuzzo et al.
    Computational modeling of a dynamin-constricted membrane neck can rank proposed shape changes of the helical scaffold in terms of their fission aptitude and elucidate the associated pathways.

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