60 results found
    1. Physics of Living Systems
    2. Stem Cells and Regenerative Medicine

    Global and local tension measurements in biomimetic skeletal muscle tissues reveals early mechanical homeostasis

    Arne D Hofemeier, Tamara Limon ... Timo Betz
    Combining global and local force measurements of reconstituted muscle tissue using a new chamber system that is compatible with high-resolution microscopy shows mechanical homeostasis already within a week.
    1. Stem Cells and Regenerative Medicine

    The mini-IDLE 3D biomimetic culture assay enables interrogation of mechanisms governing muscle stem cell quiescence and niche repopulation

    Erik Jacques, Yinni Kuang ... Penney M Gilbert
    A user-friendly, and modular, 3D skeletal muscle culture assay enables iterative studies of murine muscle stem cell pool size regulation, functional heterogeneity, return to quiescence, and age-associated functional defects within a 96-well footprint.
    1. Physics of Living Systems

    Diameter dependence of transport through nuclear pore complex mimics studied using optical nanopores

    Nils Klughammer, Anders Barth ... Cees Dekker
    Nuclear pore complex mimics based on solid-state nanopores show significant selectivity below a diameter of 55 nm, which decreases gradually for larger pore diameters.
    1. Biochemistry and Chemical Biology

    Control of lipid domain organization by a biomimetic contractile actomyosin cortex

    Sven Kenjiro Vogel, Ferdinand Greiss ... Petra Schwille
    Building on previous work (Vogel et al., 2013b), it is shown that myosin-driven actin filament rearrangements actively move, split or fuse individual lipid domains and change their overall shape.
    1. Physics of Living Systems

    In-line swimming dynamics revealed by fish interacting with a robotic mechanism

    Robin Thandiackal, George Lauder
    Fish in the thrust wake of a flapping foil reduce tail-beat frequencies, synchronize with oncoming vortices, and swim energetically more efficiently.
    1. Structural Biology and Molecular Biophysics

    Spatial structure of disordered proteins dictates conductance and selectivity in nuclear pore complex mimics

    Adithya N Ananth, Ankur Mishra ... Cees Dekker
    Biomimetic nanopores reveal that the sequence-dependent spatial distribution of intrinsically disordered proteins plays a crucial role in establishing the selective permeability barrier of the nuclear pore complex.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Engineering induction of singular neural rosette emergence within hPSC-derived tissues

    Gavin T Knight, Brady F Lundin ... Randolph Scott Ashton
    A bioengineering approach identifies tissue morphology as an effective variable for controlling the inception of neural organoid morphogenesis via induction of a biomimetic, singular neural rosette tissue cytoarchitecture.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Temperature evolution following joint loading promotes chondrogenesis by synergistic cues via calcium signaling

    Naser Nasrollahzadeh, Peyman Karami ... Dominique P Pioletti
    The loading-induced temperature evolution phenomenon in the knee joint modulates chondrogenic cells response to loading and accordingly opens a new paradigm that is coined 'thermo-mechanobiology'.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Enhancing and inhibitory motifs regulate CD4 activity

    Mark S Lee, Peter J Tuohy ... Michael S Kuhns
    Eutherian CD4 evolved counterbalancing motifs in the extracellular, transmembrane, and intracellular domains that regulate CD4+ T cell responses to peptide antigens presented by class II MHC (pMHCII).
    1. Neuroscience

    Restoring vestibular function during natural self-motion: Progress and challenges

    Kantapon Pum Wiboonsaksakul, Olivia ME Leavitt Brown, Kathleen E Cullen
    Fully incorporating our current understanding of vestibular neurophysiology into prosthesis design and clinical application will be integral to the development of the next generation of vestibular prostheses.

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