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    1. Physics of Living Systems

    Interplay of condensate material properties and chromatin heterogeneity governs nuclear condensate ripening

    Deb Sankar Banerjee, Tafadzwa Chigumira ... Huaiying Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Structural Biology and Molecular Biophysics
    2. Plant Biology

    Molecular dynamics simulations illuminate the role of sequence context in the ELF3-PrD-based temperature sensing mechanism in plants

    Richard J Lindsay, Rafael Giordano Viegas ... Sonya M Hanson
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Physics of Living Systems

    A scale-invariant log-normal droplet size distribution below the critical concentration for protein phase separation

    Tommaso Amico, Samuel Toluwanimi Dada ... Amos Maritan
    The scaling invariance of the droplet size distribution as a universal aspect of protein phase separation is reported, providing a quantitative approach to determinate the critical concentration for this process.
    1. Structural Biology and Molecular Biophysics

    Direct and indirect salt effects on homotypic phase separation

    Matt MacAinsh, Souvik Dey, Huan-Xiang Zhou
    All-atom molecular dynamics simulations revealed both direct and indirect salt effects and led to an amino-acid composition-based predictor for four classes of salt dependence of IDP phase separation.
    1. Developmental Biology

    MED26-enriched condensates drive erythropoiesis through modulating transcription pausing

    Shicong Zhu, Xiaoting Zhang ... Hsiang-Ying Lee
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging neurons

    Mofida Abdelmageed, Premkumar Palanisamy ... Anirban Paul
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    The interplay between biomolecular assembly and phase separation

    Giacomo Bartolucci, Ivar S Haugerud ... Christoph A Weber
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Elucidating ATP’s role as solubilizer of biomolecular aggregate

    Susmita Sarkar, Saurabh Gupta ... Jagannath Mondal
    ATP prevents condensation of aggregation-prone intrinsically disordered protein by modulating its conformation.
    1. Cell Biology

    Image Correlation Spectroscopy is a Robust Tool to Quantify Cellular DNA Damage Response

    Angelica A Gopal, Bianca Fernandez ... J Matthew Dubach
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression

    Heat Shock Factor 1 forms nuclear condensates and restructures the yeast genome before activating target genes

    Linda S Rubio, Suman Mohajan, David S Gross
    In response to ethanol stress, the yeast transcription factor Hsf1 forms nuclear condensates and drives the coalescence of target genes prior to their transcriptional activation while in response to thermal stress these three phenomena are tightly coordinated.
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