Human sensory neurons may not only bridge a critical gap between drug discovery and clinical trials, but force a re-evaluation of basic assumptions about the mechanisms controlling primary afferent excitability.
Gisela Rangel-Yescas, Cecilia Cervantes ... Leon D Islas
Proton channels are present in reef-building corals and constitute important molecular players that should help understand calcification and the response of these organisms to ocean acidification.
Juliette Boeri, Claude Meunier ... Antonny Czarnecki
A simple mechanism, based on the synergy of two major opposing voltage-dependent currents that are ubiquitous in neurons, produces functional diversity of developing Renshaw cells in the embryo.
Competition between adhesive and tensile forces regulates axon fasciculation, thus introducing a new role of mechanical tension in the development of neural networks.
Marc Chevalier, Natalia Toporikova ... Muriel Thoby-Brisson
Pacemaker neurons are present in the preBötC circuitry of mouse embryos and their role in driving respiratory network activity changes during the critical period immediately before birth.
Perceptual haptic representation of materials emerges from unsupervised learning as a consequence of efficient encoding of the physical signals at the input of tactile sensory system.
Martial A Dufour, Adele Woodhouse ... Jean-Marc Goaillard
The development of the electrical phenotype of neurons can be precisely quantified and dissected using a combination of multi-variate statistical analyses and a systematic electrophysiological characterization of electrical properties.
Neurite geometry enables expansive and highly-branched neuronal structures to operate like single electrical compartments and simple linear integrators.
Marcel Beining, Lucas Alberto Mongiat ... Peter Jedlicka
T2N, a novel interface between Matlab, TREES toolbox and NEURON, was used to generate compartmental models that reproduce the electrophysiology of dentate granule cells over a multitude of species, experimental conditions and developmental stages.
Christopher T Boughter, Martin Meier-Schellersheim
A comprehensive computational study of germline-encoded T cell receptor CDR loops and MHC alpha-helices finds limited evidence for evolutionary conserved interactions, and instead suggests broad biophysical compatibility guides the interactions between the two proteins.
