1,965 results found
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Simple biophysics underpins collective conformations of the intrinsically disordered proteins of the Nuclear Pore Complex

    Andrei Vovk et al.
    Simple biophysical considerations explain the collective behavior of molecularly diverse complex protein assemblies that regulate transport between the nucleus and the cytoplasm in eukaryotic organisms.
    1. Computational and Systems Biology
    2. Neuroscience

    Biophysical mechanisms in the mammalian respiratory oscillator re-examined with a new data-driven computational model

    Ryan S Phillips et al.
    Computational modeling motivated by recent experiments clarifies biophysical mechanisms generating the rhythm and amplitude of breathing at the level of neurons and brain circuits in mammals.
    1. Neuroscience

    Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1

    Nengyin Sheng et al.
    Auxiliary subunits Neto1 and Neto2 regulate the GluK1 receptor targeting to excitatory silent synapses through different molecular mechanisms and also modify receptor biophysics through distinct mechanisms.
    1. Neuroscience

    Biophysics of object segmentation in a collision-detecting neuron

    Richard Burkett Dewell, Fabrizio Gabbiani
    Active dendritic processing enables an individual neuron to discriminate the spatial pattern of synaptic inputs, increasing neural and behavioral selectivity for escaping an impending threat.
    1. Physics of Living Systems

    Biophysical properties of single rotavirus particles account for the functions of protein shells in a multilayered virus

    Manuel Jiménez-Zaragoza et al.
    In triple-layered rotavirus particles, strong interaction between the external and middle layers provides high mechanical strength for protection tasks, while weaker interaction between the middle and inner layers favors transcription.
    1. Computational and Systems Biology
    2. Neuroscience

    Biophysical models reveal the relative importance of transporter proteins and impermeant anions in chloride homeostasis

    Kira M Düsterwald et al.
    Mathematical models with experimental validation show that chloride transporters in the cell membrane, and not negatively charged impermeant molecules, generate the driving force used by GABA receptors to silence neurons.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    A simple biophysical model emulates budding yeast chromosome condensation

    Tammy MK Cheng et al.
    A computational model of a yeast chromosome, based on first principles, recapitulates in vivo chromosome behavior, and thus provides unprecedented insight into what the inside of a chromosome is likely to look like.
    1. Physics of Living Systems

    Biophysics: Common concepts for bacterial collectives

    Hannah Jeckel et al.
    The expansion of bacterial swarms and the spreading of biofilms can be described by a unified biophysical theory that involves both active and passive processes.
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    1. Computational and Systems Biology
    2. Physics of Living Systems

    Biophysical clocks face a trade-off between internal and external noise resistance

    Weerapat Pittayakanchit et al.
    Molecular clocks that are robust to external fluctuations are vulnerable to internal fluctuations and vice versa.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Synergy between RecBCD subunits is essential for efficient DNA unwinding

    Rani Zananiri et al.
    A new optical tweezers assay sheds light on the mechanism of cooperation and force generation by the subunits of RecBCD, critical for the repair of double strand breaks in bacteria.

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