Short linear motifs throughout the intrinsically disordered proteome use sequence context in diverse ways to target actin remodeler ENAH.

Our latest Special Issue brings together research on the allosteric regulation of kinase activity.

A peptide from PCARE achieves >100-fold binding specificity for the EVH1 domain of ENAH, a protein important for metastasis, using a conformational shift mechanism unavailable to ENAH's closely related paralogs VASP and EVL.

MDGAs are highly diffusive molecules that alter both neuroligin-1 and AMPA receptor dynamics and function, thereby significantly delaying the differentiation of excitatory post-synapses.

Effector target-guided engineering has developed plant NLR immune receptors that bind and recognize stealthy pathogen effector proteins, demonstrating new disease resistance profiles in planta, and offering a promising approach to protect crops against plant pathogens.

Independent dating techniques have established that the H. naledi fossils are between 236 and 335 thousand years old, indicating that small-brained hominins with relatively primitive body shapes co-existed with our early ancestors in Africa.

The lysosomal ion channel TPC2 emerges as an example of an ion channel in which ion selectivity is not fixed but rather agonist-selective.

Neural sensory representations impose an inductive bias over the space of learning tasks, allowing some tasks to be learned by a downstream neuron more sample-efficiently than others.

A high-throughput method to profile tyrosine kinases and phosphotyrosine recognition domains reveals new rules for sequence specificity and maps the effects of mutations on the recognition of tyrosine phosphorylation sites.

The value of any choice is not static but dynamically changes as a function of the context of the alternatives even if they are seemingly irrelevant.