Kira M Düsterwald, Christopher B Currin ... Joseph V Raimondo
Mathematical models with experimental validation show that chloride transporters in the cell membrane, and not negatively charged impermeant molecules, generate the driving force used by GABA receptors to silence neurons.
Atle E Rimehaug, Alexander J Stasik ... Anton Arkhipov
A biophysically detailed model of mouse primary visual cortex reproduces, in a quantitative manner, experimentally recorded spikes and local field potentials, and suggests mechanisms that form current sinks and sources in vivo.
A biophysical model of the process by which bacteria transition from the motile planktonic state to the immobilized biofilm state yields testable predictions in terms of two dimensionless parameters, one describing nutrient availability and the other describing cellular dispersal.
Computational modeling suggests that the BLA is capable of producing the recorded LFP rhythms via interactions of interneuron subtypes, and that those rhythms may be necessary for associative learning.
Live-cell single-molecule imaging of DNA repair factors can be used to analyze their localization to DNA lesions and dissect the hierarchy of their recruitment.
Vincent Fontanier, Matthieu Sarazin ... Emmanuel Procyk
Single unit recordings in monkeys and biophysical modelling demonstrate that local inhibitory-controlled metastable neural states specify the temporal organization of cognitive functions in frontal areas.
Ryan S Phillips, Hidehiko Koizumi ... Jeffrey C Smith
The predictive power of a computational model advances understanding of the neuronal and circuit biophysical mechanisms that generate the respiratory rhythm and neural activity patterns in the mammalian brainstem.
Eva E Deinum, Bela M Mulder, Yoselin Benitez-Alfonso
A new biophysical model enables the reconciliation of ultrastructural and tissue level measurements on parameters affecting intercellular communication, and provides novel functional insight into experimental findings.
Computational modeling motivated by recent experiments clarifies biophysical mechanisms generating the rhythm and amplitude of breathing at the level of neurons and brain circuits in mammals.
Auxiliary subunits Neto1 and Neto2 regulate the GluK1 receptor targeting to excitatory silent synapses through different molecular mechanisms and also modify receptor biophysics through distinct mechanisms.
