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50 results found
    1. Cancer Biology
    2. Physics of Living Systems

    Collective forces of tumor spheroids in three-dimensional biopolymer networks

    Christoph Mark et al.
    The forces that multicellular tumor aggregates exert on their environment lead to non-linear, scale-invariant tissue deformations far away from the tumor, which can be exploited to quantify its collective contractility.
    1. Physics of Living Systems

    High-molecular-weight polymers from dietary fiber drive aggregation of particulates in the murine small intestine

    Asher Preska Steinberg et al.
    Polymers from dietary fiber can control the aggregation of particulates in the murine small intestine in a manner qualitatively consistent with depletion interactions.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms

    Alessandro Scacchetti et al.
    Alternative splicing of a single gene generates functional diversity amongst chromatin regulators.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Electrostatic lateral interactions drive ESCRT-III heteropolymer assembly

    Sudeep Banjade et al.
    ESCRT-III heteropolymers utilize non-specific lateral electrostatic interactions to recognize one another, which may enable the polymers to slide along one another and adapt to different curvatures.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Intrinsic cooperativity potentiates parallel cis-regulatory evolution

    Trevor R Sorrells et al.
    Cooperativity between two transcription regulators occurs through protein-protein interactions with a general transcription factor complex and potentiates the parallel evolution of their DNA binding sites.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment

    James E Gomez et al.
    Mutations in several components of a bacterial ribosome are shown to broadly decrease antibiotic and stress sensitivity, and readily accessible reversion mutations allow these ribosomal mutations to serve as stepping stones to high level antibiotic resistance.
    1. Microbiology and Infectious Disease

    Structural basis of host recognition and biofilm formation by Salmonella Saf pili

    Longhui Zeng et al.
    SafDAA-SafDAA structure and functional characterizations reveal a pili-mediated inter-cellular oligomerization mechanism for bacterial aggregation and biofilm formation in Salmonella enterica.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Live-cell mapping of organelle-associated RNAs via proximity biotinylation combined with protein-RNA crosslinking

    Pornchai Kaewsapsak et al.
    Live-cell nanometer-resolution RNA labeling method enables transcriptome-wide mapping of endogenous RNAs in nuclear, cytosol, ER, and mitochondrial subcompartments.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3

    Ksenia Finogenova et al.
    Nucleosome binding by PRC2 threads H3K27 into its active site via an interaction network set in register by unmodified H3K36.
    1. Physics of Living Systems
    2. Cell Biology

    The axonal actin-spectrin lattice acts as a tension buffering shock absorber

    Sushil Dubey et al.
    A linear array of spectrin tetramers imparts mechanical stability to axons by allowing spectrin domains to unfold reversibly when an axon is stretched, thereby acting as tension buffers.

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